60435-90-7 Usage
Description
6-O-Methyl Mycophenolic Acid Methyl Ester is an organic compound that is identified as an impurity in Mycophenolic Acid, an antibiotic derived from certain species of Penicillium fungi. It is characterized by its molecular structure and properties, which differentiate it from the primary compound.
Uses
Used in Pharmaceutical Industry:
6-O-Methyl Mycophenolic Acid Methyl Ester is used as an impurity in the production of Mycophenolic Acid (M831500), which is an antibiotic. Mycophenolic Acid functions as a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme that plays a role in the de novo synthesis of purine nucleotides.
Used in Environmental Contaminant Analysis:
6-O-Methyl Mycophenolic Acid Methyl Ester is utilized in the identification and analysis of environmental contaminants. Its presence can indicate potential contamination in various environmental samples, which is crucial for monitoring and maintaining environmental safety.
Used in Food Contaminant Analysis:
In the food industry, 6-O-Methyl Mycophenolic Acid Methyl Ester is used for detecting food contaminants. Its identification in the food supply can signal the presence of unwanted substances, which is essential for ensuring food safety and quality.
Check Digit Verification of cas no
The CAS Registry Mumber 60435-90-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,4,3 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 60435-90:
(7*6)+(6*0)+(5*4)+(4*3)+(3*5)+(2*9)+(1*0)=107
107 % 10 = 7
So 60435-90-7 is a valid CAS Registry Number.
60435-90-7Relevant articles and documents
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment
Chen, Liqiang,Wilson, Daniel,Jayaram, Hiremagalur N.,Pankiewicz, Krzysztof W.
, p. 6685 - 6691 (2008/09/18)
Mycophenolic acid (MPA), an inhibitor of IMP-dehydrogenase (IMPDH), is used worldwide in transplantation. Recently, numerous studies showed its importance in cancer treatment. Consequently, MPA entered clinical trials in advanced multiple myeloma patients
Total synthesis of mycophenolic acid
Covarrubias-Zú?iga, Adrián,Gonzalez-Lucas, Armando,Domínguez, Mireya M.
, p. 1989 - 1994 (2007/10/03)
A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid 1.
Convenient O-methylation of phenols with dimethyl carbonate
Lee, Youngmin,Shimizu, Isao
, p. 1063 - 1064 (2007/10/03)
Reaction of phenols in dimethyl carbonate in the presence of cesium carbonate at 120-160° C gave aryl methyl ethers in good yields, whereas the reaction of aliphatic alcohols gave the corresponding alkyl carbonates. This method provides a useful synthetic method for preparation of various aryl methyl ethers without using toxic methyl iodide or dimethyl sulfate. O-Methylation of the aromatic hydroxy group of estradiol was carried out in 2 steps without protection of the alcoholic hydroxy group in the same molecule.
