6048-06-2

Basic information

• Product Name: ETHYL 4-CHLOROCINNAMATE
• Synonyms: ETHYL 4-CHLOROCINNAMATE;4-CHLOROCINNAMIC ACID ETHYL ESTER;2-PROPENOIC ACID, 3-(4-CHLOROPHENYL)-ETHYL ESTER;4-Chloroethyl cinnamate;(E)-3-(4-Chlorophenyl)acrylic acid ethyl ester;(E)-3-(4-Chlorophenyl)propenoic acid ethyl ester;(E)-4-Chlorocinnamic acid ethyl ester;Ethyl 4-chloro-trans-cinnamate
• CAS NO: 6048-06-2
• Molecular Formula: C₁₁H₁₁ClO₂
• Molecular Weight: 210.66
• Product Categories: Aromatic Cinnamic Acids, Esters and Derivatives
• Mol File: 6048-06-2.mol
• Article Data: 51

Chemical Properties

• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 151.9 °C
• Appearance: /
• Density: 1.177 g/cm³
• Vapor Pressure: 0.000703mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: ETHYL 4-CHLOROCINNAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-CHLOROCINNAMATE(6048-06-2)
• EPA Substance Registry System: ETHYL 4-CHLOROCINNAMATE(6048-06-2)

Safety Data

• Hazardous Substances Data: 6048-06-2(Hazardous Substances Data)

Usage

General Description

Ethyl 4-chlorocinnamate is a chemical compound with the molecular formula C11H11ClO2. It is an ester, which is a derivative of cinnamic acid. Ethyl 4-chlorocinnamate is commonly used in the fragrance and flavor industry due to its sweet, fruity, and floral aroma. It is also used as a flavoring agent in food and beverages. Additionally, it has potential applications in the pharmaceutical industry as it exhibits antimicrobial and antioxidant properties, making it a potential candidate for pharmaceutical formulations. However,

InChI:InChI=1/C11H11ClO2/c1-2-14-11(13)8-5-9-3-6-10(12)7-4-9/h3-8H,2H2,1H3/b8-5+

Upstream product

• 1615-02-7 p-chlorocinnamic acid 
• 64-17-5 ethanol 
• 38897-99-3 (4-Chlorophenylmethylene)triphenylphosphorane 
• 105-36-2 ethyl bromoacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 54762-78-6 4-(4-chloro-phenyldiazenyl)-morpholine 
• 140-88-5 ethyl acrylate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 106-39-8 bromochlorobenzene 
• 78-39-7 Triethyl orthoacetate 
• 1530-45-6 (carbethoxymethyl)triphenylphosphonium bromide 
• 201221-71-8 fluoro-ethoxycarbonyl-methylene triphenylphosphine 
• 637-87-6 1-Chloro-4-iodobenzene 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 7116-36-1 ethyl 3-(4-chlorophenyl)propanoate 
• 52451-48-6 6-(4-Chloro-phenyl)-4-ethoxy-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester 
• 102697-21-2 3-(4-Chloro-phenyl)-5-oxo-4,5-diphenyl-pentanoic acid ethyl ester 
• 102697-22-3 3-(4-Chloro-phenyl)-5-oxo-4,5-diphenyl-pentanoic acid ethyl ester 
• 144707-85-7 3-(4-Chloro-phenyl)-3-trimethylsilanyl-propionic acid ethyl ester 
• 14062-29-4 ethyl 2-(3-chlorophenyl)acetate 
• 18166-64-8 4-chlorocinnamide 
• 77418-81-6 3-(3-Chloro-phenyl)-4-(4-chloro-phenyl)-piperidine-2,6-dione 
• 77418-82-7 4-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-piperidine-2,6-dione 
• 587-88-2 ethyl 2-(4-fluorophenyl)acetate 
• 587-47-3 3-fluorophenylacetic acid ethyl ester 
• 77418-80-5 4-(4-Chloro-phenyl)-3-(3-fluoro-phenyl)-piperidine-2,6-dione 
• 584-74-7 o-fluorophenylacetic acid ethyl ester 
• 77418-79-2 4-(4-Chloro-phenyl)-3-(2-fluoro-phenyl)-piperidine-2,6-dione 

Relevant articles and documents

Palladium-Catalyzed Allyl-Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2as Sole Reductant

Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.

Synthesis method of isochroman compound

The invention discloses a synthesis method of an isochroman compound, which comprises the following steps of adding dichloromethane and phosphorus tribromide into 3, 4, 5-trimethoxy benzyl alcohol, and reacting to obtain 1-bromomethyl-3, 4, 5-trimethoxy benzene, adding tetrahydrofuran, cinnamyl alcohol, sodium hydride and 1-bromomethyl-3, 4, 5-trimethoxybenzene into a reactor, and reacting to obtain 1-[(cinnamyl oxy)methyl]-3, 4, 5-trimethoxybenzene, adding cyanuric acid into a reactor containing a potassium hydroxide aqueous solution to react, dropwise adding a silver nitrate aqueous solution, and reacting to obtain silver isocyanurate, adding silver isocyanurate, phenyl selenium bromide and anhydrous dichloromethane into a reactor, and reacting to obtain N, N, N-triphenyl seleno isocyanurate, reacting N, N, N-triphenyl seleno isocyanurate, dichloromethane, boron trifluoride diethyl etherate and a 1-[(cinnamyl oxy)methyl]-3, 4, 5-trimethoxybenzene compound to obtain a target product. The method is simple in reaction operation, mild in reaction condition, relatively high in yield and environment-friendly.

Palladium Immobilized on 2,2′-Dipyridyl-Based Hypercrosslinked Polymers as a Heterogeneous Catalyst for Suzuki–Miyaura Reaction and Heck Reaction

Abstract: 2,2′-Bipyridine was successfully integrated into the skeleton of hypercrosslinked polymers networks (HCPs-bipy) via Friedel–Crafts reaction and Scholl coupling reaction, and PdCl2 was locked in this network polymers by coordination with pyridine motif. The preparation of HCPs-bipy has the advantages of low cost, mild conditions, easy separation and high yield. FT-IR, TGA, N2 sorption, ICP, XPS, SEM, EDX and TEM was employed to characterize the structure and composition of the heterogeneous catalysts. The result indicates that HCPs-bipy-Pd possess high specific surface areas, large microporous volume, thermal stability, and highly dispersion of palladium species. HCPs-bipy-Pd can be applied in Suzuki–Miyaura reactions and Heck reactions as robust heterogeneous catalyst to afford high yield. The reusability test demonstrates that HCPs-bipy-Pd could be recovered and reused for at least five times without losing catalytic activity. Graphic Abstract: [Figure not available: see fulltext.].