60547-96-8 Usage
Description
6,7-Dimethoxyquinazoline-2,4-diamine is an organic compound with the molecular formula C10H13N3O2. It is a derivative of quinazoline, a tricyclic fused pyridine-pyrimidine ring system, and features two amine groups at the 2 and 4 positions, as well as methoxy groups at the 6 and 7 positions. 6,7-Dimethoxyquinazoline-2,4-diamine is known for its potential biological activities and applications in various fields.
Uses
Used in Pharmaceutical Industry:
6,7-Dimethoxyquinazoline-2,4-diamine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
As a metabolite of Terazosin (T105000) and a minor metabolite of Prazosin (P702325), 6,7-Dimethoxyquinazoline-2,4-diamine is utilized in medicinal chemistry research to study the structure-activity relationships of these drugs. This helps in the design and optimization of new compounds with improved pharmacological properties.
Used in Hypertension Treatment:
6,7-Dimethoxyquinazoline-2,4-diamine displays high affinity for the α1-Adrenoceptors, which play a crucial role in the regulation of blood pressure. Its interaction with these receptors makes it a potential candidate for the development of drugs aimed at treating hypertension.
Check Digit Verification of cas no
The CAS Registry Mumber 60547-96-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,4 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60547-96:
(7*6)+(6*0)+(5*5)+(4*4)+(3*7)+(2*9)+(1*6)=128
128 % 10 = 8
So 60547-96-8 is a valid CAS Registry Number.
60547-96-8Relevant articles and documents
Synthesis and identification of the major metabolites of prazosin formed in dog and rat
Althuis,Hess
, p. 146 - 149 (2007/10/05)
The 6 O demethyl and 7 O demethyl analogues of the new antihypertensive drug prazosin [2 [4 (2 furoyl) piperazin 1 yl] 4 amino 6,7 dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate ten step reaction sequences starting from isovanillin and vanillin, respectively. The 6 O demethyl derivative was found to be identical with the major prazosin metabolite formed in dog and rat, while the 7 O demethyl derivative was identical with another, less prevalent but significant metabolite. Two minor metabolites of prazosin, 2 (1 piperazinyl) 4 amino 6,7 dimethoxyquinazoline and 2,4 diamino 6,7 dimethoxyquinazoline, are also described. All four metabolites are less potent blood pressure lowering agents in dogs than prazosin but may contribute to its antihypertensive effect, since they account for a major portion of the administered dose.
