60561-82-2Relevant articles and documents
Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol
Biswal, Priyabrata,Samser, Shaikh,Meher, Sushanta Kumar,Chandrasekhar, Vadapalli,Venkatasubbaiah, Krishnan
, p. 413 - 419 (2021/11/01)
One-pot synthesis of α-methyl ketones starting from 1,3-diaryl propenols or 1-aryl propenols and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by commercially available Pd(OAc)2 with H2O as the only by-product. Mechanistic studies and deuterium labelling experiments indicate the involvement of isomerization of allyl alcohol followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.
Method for preparing aryl ketone based on iron-catalyzed free radical-free radical coupling reaction such as ketonic acid decarboxylation and fatty aldehyde de-carbonylation
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Paragraph 0051-0052, (2020/05/05)
The invention discloses a method for preparing an aryl ketone derivative based on a free radical-free radical cross-coupling reaction such as ketonic acid decarboxylation and fatty aldehyde de-carbonylation. The method comprises the following steps: reacting aryl-substituted ketonic acid with fatty aldehyde under the catalytic action of ferric triacetylacetonate to generate an aryl ketone derivative; the gram-grade reaction can be realized by the method only by using 3mol% of an iron catalyst; and the method has the advantages of no need of consumption of a large amount of a Lewis acid catalyst or a stoichiometric organic metal reagent, mild reaction conditions, one-step reaction, few by-products, wide substrate application range and scalable reaction, and overcomes the defects of large catalyst consumption, insufficient functional group tolerance, many by-products and the like in the prior art.
Process for preparing photoinitiator 185
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Paragraph 0035; 0037; 0039; 0041; 0043; 0045, (2019/01/16)
The invention provides a process for preparing a photoinitiator 185 and belongs to the field of photoinitiator preparation processes. The process includes a high temperature ketone preparing process:liquefy and mixing tert-butylbenzoic acid and iso-butyric acid and then obtaining a reaction mixed liquid, preheating the reaction mixed liquid and causing the reaction mixed liquid to come into contact with a metal salt catalyst, removing carbon dioxide through dehydration at a high temperature (300-500 DEG C) to manufacture ketone, and obtaining 2-methyl-1-[4-(tert-butyl)phenyl]-1-acetone; a one-pot method chlorination alkaline hydrolysis process: taking 2-methyl-1-[4-(tert-butyl)phenyl]-1-acetone, taking carbon tetrachloride and sodium hydroxide as reagents, taking tetrabutylammonium bromide as a phase transfer catalyst, and performing one-pot method chlorination and alkaline hydrolysis to obtain 2-hydroxyl-2-methyl-1-[4-(tert-butyl)phenyl]-1-acetone. According to the process, the use of hazardous chemicals such as phosphorus trichloride, aluminum trichloride and flammable carcinogenic raw material benzene in the prior art is eliminated, and the safety and environmental protection pressure of the whole process is effectively improved, and the treatment cost of three wastes is greatly reduced.