605680-62-4

Basic information

• Product Name: 2-Methyl-2-[(5-trifluoromethylpyridin-2-yl)oxy]propionic acid
• Synonyms: 2-Methyl-2-[(5-trifluoromethylpyridin-2-yl)oxy]propionic acid;2-methyl-2-(5-(trifluoromethyl)pyridin-2-yloxy)propanoic acid;Propanoic acid, 2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-;2-methyl-2-(5-(trifluoromethyl)pyridin;2-Methyl-2-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]-
• CAS NO: 605680-62-4
• Molecular Formula: C₁₀H₁₀F₃NO₃
• Molecular Weight: 249.19
• Product Categories: API intermediates
• Mol File: 605680-62-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 306.607oC at 760 mmHg
• Flash Point: 139.231oC
• Appearance: /
• Density: 1.352g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-2-[(5-trifluoromethylpyridin-2-yl)oxy]propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-[(5-trifluoromethylpyridin-2-yl)oxy]propionic acid(605680-62-4)
• EPA Substance Registry System: 2-Methyl-2-[(5-trifluoromethylpyridin-2-yl)oxy]propionic acid(605680-62-4)

Safety Data

• Hazardous Substances Data: 605680-62-4(Hazardous Substances Data)

Usage

General Description

2-Methyl-2-[(5-trifluoromethylpyridin-2-yl)oxy]propionic acid is a chemical compound featuring two main components: a pyridin group, which is a ring-shaped compound commonly used in pharmaceuticals due to its properties as a conductor and acceptor of electrons; and a trifluoromethyl group that can increase a compound’s stability and lipophilicity, enhancing its pharmacological activity. When combined, these groups form a compound with a carboxylic acid group attached, lending it the acidic properties indicated in its name. This chemical compound may have several uses in medicinal chemistry for its electron-conductive properties and its potential ability to increase activity of pharmaceutical agents.

InChI:InChI=1/C10H10F3NO3/c1-9(2,8(15)16)17-7-4-3-6(5-14-7)10(11,12)13/h3-5H,1-2H3,(H,15,16)

Upstream product

• 913849-17-9 ethyl 2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoate 
• 33252-63-0 2-hydroxy-5-(trifluoromethyl)pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 
• 80-55-7 ethyl 2-hydroxy-2,2-dimethylethanoate 

Downstream Products

• 701977-09-5 taranabant 
• 701977-00-6 N-[(1R,2R)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide 
• 721430-07-5 N-{[3-(4-chlorophenyl)-2-(3-bromophenyl)-2-hydroxy]propyl}-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide 
• 947371-19-9 C₂₇H₂₄ClF₄N₃O₂ 
• 605679-35-4 N-[2-(3-cyano-5-fluoro-phenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide 
• 1092698-93-5 N-[(2S,3R)-4-(4-chlorophenyl)-3-(3-cyanophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl]-2-methyl-2-[5-(trifluoromethyl)pyridin-2-yloxy]propanamide 
• 1097207-71-0 C₂₈H₂₈Cl₂F₃N₃O₄ 
• 1244978-13-9 C₂₇H₂₇BrClF₃N₂O₂ 
• 1244978-30-0 C₂₆H₂₄ClF₃N₂O₂ 
• 1244978-34-4 C₂₇H₂₆ClF₃N₂O₂ 
• 1244978-38-8 C₂₈H₂₈ClF₃N₂O₂ 
• 1356556-88-1 4-(4-fluoro-3-(4-(2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanoyl)piperazine1l-carbonyl)benzyl)phthalazin-1(2H)-one 
• 876365-70-7 N-[(1Z)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylprop-1-en-1-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide 
• 876365-72-9 3-{(1S,2S)-1-(4-chlorobenzyl)-2-[(2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanoyl)amino]propyl}benzamide 

Relevant articles and documents

SUBSTITUTED 4-(4-FLUORO-3-(PIPERAZINE-1- CARBONYL)BENZYL)PHTHALAZIN-1(2H)-ONE DERIVATIVES AS POLY (ADP-RIBOSE) POLYMERASE- 1 INHIBITORS

Disclosed are compounds of general formula (I), their stereoisomers, regioisomers, tautomeric forms and novel intermediates involved in their synthesis, their pharmaceutically acceptable salts. These compounds are suitable as Poly (ADP-ribose) polymerase- 1 inhibitors (PARP-1 inhibitors).

Discovery of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1- methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity

The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in rodent models of food intake and body weight reduction. A major focus of the optimization process was to increase in vivo efficacy and to reduce the potential for formation of reactive metabolites. These efforts led to the identification of compound 48 for development as a clinical candidate for the treatment of obesity.

ACYCLIC HYDRAZIDES AS CANNABINOID RECEPTOR MODULATORS

The acyclic hydrazides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present inventio