60597-72-0

Basic information

• Product Name: 4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine
• Synonyms: 4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine 97%;4-(2-Chloropyridin-3-ylsulfonyl)morpholine;4-[(2-Chloropyridin-3-yl)sulfonyl]morpholine;4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine97%;2-Chloro-3-(morpholin-4-ylsulphonyl)pyridine;4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine
• CAS NO: 60597-72-0
• Molecular Formula: C9H11ClN2O3S
• Molecular Weight: 262.71324
• Product Categories: blocks;Pyridines
• Mol File: 60597-72-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 437.3 °C at 760 mmHg
• Flash Point: 218.3 °C
• Appearance: /
• Density: 1.451 g/cm³
• Vapor Pressure: 7.56E-08mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine(60597-72-0)
• EPA Substance Registry System: 4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine(60597-72-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 60597-72-0(Hazardous Substances Data)

Usage

General Description

4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine is a chemical compound that combines the compounds morpholine and 2-chloropyridine through a sulfonyl linker. This organic compound is categorized as a sulfone and a member of pyridines and morpholines. Morpholines are a class of organic chemicals that contain a six-membered ring with four carbon atoms, one oxygen atom, and one nitrogen atom. Pyridines are a class of aromatic compounds that contain a six-membered ring with five carbon atoms and one nitrogen atom. The potential uses and properties of this compound would depend on the specific bioactivity or chemical characteristics coming from the interaction of these components and the sulfonyl linker. Specific information about these, such as toxicity or health risks, or industrial or pharmaceutical applications, would need to be obtained from experimental data or safety datasheets.

InChI:InChI=1/C9H11ClN2O3S/c10-9-8(2-1-3-11-9)16(13,14)12-4-6-15-7-5-12/h1-3H,4-7H2

Upstream product

• 110-91-8 morpholine 
• 6684-06-6 2-chloro-3-pyridinesulfonyl chloride 

Downstream Products

• 74186-30-4 4-(2-hydrazinylpyridin-3-ylsulfonyl)morpholine 

Relevant articles and documents

A novel series of [1,2,4]triazolo[4,3-a]pyridine sulfonamides as potential antimalarial agents: In silico studies, synthesis and in vitro evaluation

For the development of new and potent antimalarial drugs, we designed the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment. The library of 1561 compounds has been investigated by both virtual screening and molecular docking methods using falcipain-2 as a target enzyme. 25 chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC50 = 2.24 and 4.98 μM, respectively. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs.

SYNTHESIS AND PROPERTIES OF PYRIDINE- AND s-TRIAZOLOPYRIDINESULFONAMIDES

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