607366-20-1

Basic information

• Product Name: Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-BETA-(1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL)-L-2,3-DIAMINOPROPIONIC ACID;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-BETA-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-2,3-DIAMINOPROPIONIC ACID;N-ALPHA-FMOC-N-BETA-1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-DIAMINOPROPIONIC ACID;FMOC-N-BETA-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL-L-2,3-DIAMINOPROPIONIC ACID;FMOC-DPR(IVDDE)-OH;FMOC-DAP(IVDDE)-OH;FMOC-L-DAP(IVDDE)-OH;3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
• CAS NO: 607366-20-1
• Molecular Formula: C31H36N2O6
• Molecular Weight: 532.63
• Product Categories: amino acid;amino acids
• Mol File: 607366-20-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 733.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.221
• Storage Temp.: -20°C
• PKA: 3.47±0.10(Predicted)
• CAS DataBase Reference: Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine(607366-20-1)
• EPA Substance Registry System: Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine(607366-20-1)

Safety Data

• Hazardous Substances Data: 607366-20-1(Hazardous Substances Data)

Usage

Description

Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine is a complex organic compound that serves as a key building block in the synthesis of various biologically active molecules. It is characterized by its unique structure, which includes a 3-methylbutylamine group connected to an L-alanine residue, as well as a 4,4-dimethyl-2,6-dioxocyclohexylidene moiety. Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine is particularly useful in the development of pharmaceuticals and other bioactive agents due to its ability to form stable conjugates with peptides and other molecules.

Uses

Used in Pharmaceutical Synthesis:
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine is used as a synthetic intermediate for the development of phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates. These conjugates act as Src kinase inhibitors, which are important targets for the treatment of various diseases, including cancer and inflammatory disorders. The unique structure of this compound allows for the formation of stable and bioactive conjugates with peptides, enhancing their therapeutic potential.
Used in Peptide Research:
Fmoc-3-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-L-alanine is also used to prepare peptidomimetic ligands for α4β1 integrin on Jurkat T-leukemia cells. These ligands are valuable tools in the study of cell adhesion, migration, and signaling processes, as well as in the development of targeted therapies for leukemia and other diseases. The incorporation of this compound into peptidomimetic structures allows for the creation of molecules with enhanced stability and selectivity for their target receptors.