60787-02-2

Basic information

• Product Name: Piperazine, 1-benzoyl-4-ethyl-
• CAS NO: 60787-02-2
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.299
• Mol File: 60787-02-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-benzoyl-4-ethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-benzoyl-4-ethyl-(60787-02-2)
• EPA Substance Registry System: Piperazine, 1-benzoyl-4-ethyl-(60787-02-2)

Safety Data

• Hazardous Substances Data: 60787-02-2(Hazardous Substances Data)

Upstream product

• 5308-25-8 4-ethylpiperazine 
• 98-88-4 benzoyl chloride 
• 13754-38-6 N-Benzoylpiperazine 
• 65-85-0 benzoic acid 
• 64-17-5 ethanol 
• 100-51-6 benzyl alcohol 
• 2902-69-4 2,2,2-trichloroacetophenone 
• 1226986-70-4 1-ethylpiperazine hydrochloride 

Downstream Products

• 5308-25-8 4-ethylpiperazine 

Relevant articles and documents

A piperazine amide preparation method of the compound (by machine translation)

The invention discloses a piperazine amides preparation method, comprising: in a solvent, the compound 1 with compound 2 to carry out the reaction, to obtain compound 3, the reaction temperature is 20 °C -120 °C; Ar is substituted or unsubstituted aryl; R is hydrogen, methyl, ethyl, propyl, benzyl, tert-butoxy carbonyl, benzyloxycarbonyl, C1 - C3 Acyl, or substituted or unsubstituted aryl; the aromatic vuill substituted ethylenically C1 - C5 Straight or branched chain alkyl, C1 - C3 Alkoxy, amino, halogen, cyano, aldehyde, C1 - C5 Acyl, trifluoromethyl and carboxyl in the one or more; the aromatic substituent is phenyl, thienyl, pyrrolyl, pyrimidinyl or pyridinyl. Preparation method of this invention mild condition, raw material properties are stable, easy to use and storage, high yield, the process is simple, low requirements on equipment, after treatment is convenient, product separation and purification is simple. (by machine translation)

Dehydrogenative amide synthesis from alcohol and amine catalyzed by hydrotalcite-supported gold nanoparticles

Hydrotalcite-supported nano-gold (Au/HT) was found to be a highly efficient heterogeneous catalyst for the dehydrogenative synthesis of amide from alcohol and amine. Amines and alcohols with different structures could be converted into the amides under mild reaction conditions with up to 98% isolated yields. Mechanism exploration suggested that ester might be the reaction intermediate.

Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors

A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.