60925-61-3 Usage
Description
Ceforanide is a second generation cephalosporin with good β-lactamase resistance.
It has a serum half-life of about three hours, allowing twice-daily dosing.
Originator
Bristol (USA)
Uses
Different sources of media describe the Uses of 60925-61-3 differently. You can refer to the following data:
1. Ceforanide is a cephalosporin based antibiotic used in the sterilization in various medical procedures.
2. Cephalosporin antibiotic
Definition
ChEBI: A second-generation cephalosporin antibiotic with {[1-(carboxymethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and 2-(aminomethyl)phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is effective against many col
forms, including Escherichia coli, Klebsiella, Enterobacter and Proteus, and most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Ari
ona species.
Brand name
Precef (Apothecon).
Antimicrobial activity
A semisynthetic parenteral cephalosporin with activity broadly
similar to that of cefalotin. Its activity in vitro is significantly
reduced in the presence of serum. A 1 g intravenous dose achieves a concentration of c. 135 mg/L at the end of infusion.
The response after 0.25, 0.5 and 1 g intravenous doses
is essentially linear. A 1 g intramuscular dose produces mean
peak values of around 70 mg/L. Plasma protein binding is
around 85%.
It is almost entirely eliminated in the urine with a halflife
of about 2.5 h, 80–95% being recovered in the first 12 h.
The half-life is inversely related to renal function, rising
to around 20 h when the creatinine clearance falls below
5 mL/min. About half the dose is removed by hemodialysis
over 6 h.
It is generally well tolerated; phlebitis and pain at the site
of injection are reported in some patients with occasional
transient neutropenia and increased transaminase levels.
It has been used principally for the treatment of infections
due to Gram-positive cocci, including staphylococcal and
streptococcal soft-tissue infections, but is no longer widely
available.
Check Digit Verification of cas no
The CAS Registry Mumber 60925-61-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,9,2 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 60925-61:
(7*6)+(6*0)+(5*9)+(4*2)+(3*5)+(2*6)+(1*1)=123
123 % 10 = 3
So 60925-61-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H21N7O6S2/c21-6-11-4-2-1-3-10(11)5-13(28)22-15-17(31)27-16(19(32)33)12(8-34-18(15)27)9-35-20-23-24-25-26(20)7-14(29)30/h1-4,15,18H,5-9,21H2,(H,22,28)(H,29,30)(H,32,33)/t15-,18-/m1/s1
60925-61-3Relevant articles and documents
IMPROVED PROCESS FOR THE PREPARATION OF CEFORANIDE IN PURE FORM
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Page/Page column 10, (2008/06/13)
The present invention provides an improved process for the preparation of the compound of formula (I) in pure form.