609770-35-6

Basic information

• Product Name: 2-(azidomethyl)pyridine(SALTDATA: FREE)
• Synonyms: 2-(azidomethyl)pyridine(SALTDATA: FREE)
• CAS NO: 609770-35-6
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.13864
• Mol File: 609770-35-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(azidomethyl)pyridine(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(azidomethyl)pyridine(SALTDATA: FREE)(609770-35-6)
• EPA Substance Registry System: 2-(azidomethyl)pyridine(SALTDATA: FREE)(609770-35-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 609770-35-6(Hazardous Substances Data)

Usage

Description

2-(azidomethyl)pyridine(SALTDATA: FREE) is a pyridine derivative featuring an azido group attached to the methyl group. This chemical compound is widely utilized in organic synthesis and chemical research, serving as a versatile precursor for the creation of various organic compounds. The azido group in 2-(azidomethyl)pyridine allows for a range of chemical reactions, such as azide-alkyne cycloaddition, which can lead to the formation of new carbon-carbon or carbon-nitrogen bonds. Additionally, this compound holds promise for applications in medicinal chemistry and pharmaceutical research. However, due to the potential explosiveness and toxicity associated with azides, careful handling is required when working with 2-(azidomethyl)pyridine. It stands as a significant building block in organic chemistry with a broad spectrum of potential applications across different fields.

Uses

Used in Organic Synthesis:
2-(azidomethyl)pyridine(SALTDATA: FREE) is used as a precursor in organic synthesis for the creation of a variety of organic compounds. Its azido group enables the formation of new carbon-carbon or carbon-nitrogen bonds through reactions such as azide-alkyne cycloaddition, making it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry and Pharmaceutical Research:
In the field of medicinal chemistry and pharmaceutical research, 2-(azidomethyl)pyridine(SALTDATA: FREE) is utilized as a building block for the development of potential drug candidates. Its unique structure and reactivity contribute to the design and synthesis of novel compounds with therapeutic potential.
Used in Chemical Research:
2-(azidomethyl)pyridine(SALTDATA: FREE) is employed in chemical research to explore the properties and reactions of azide-containing compounds. This helps in understanding the broader implications and applications of azide chemistry in various chemical processes and reactions.

Upstream product

• 4377-33-7 2-chloromethylpyridine 

Downstream Products

• 1192206-01-1 2-{[4-phenyl-1H-1,2,3-triazol-1-yl]methyl}pyridine 
• 1224434-24-5 2-(4-methoxyphenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-25-6 2-(4-fluorophenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-26-7 2-(4-nitrophenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-20-1 2-phenyl-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-21-2 N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-p-tolyldiazenecarboxamide 
• 1224434-22-3 2-(4-chlorophenyl)-N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)diazenecarboxamide 
• 1224434-23-4 N-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methyl)-2-(4-(trifluoromethyl)phenyl)diazenecarboxamide 
• 1234381-72-6 2-(4-{4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalen-1-yl}-[1,2,3]triazol-1-ylmethyl)-pyridine 
• 1227780-04-2 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-((1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 
• 1227780-11-1 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(3-(1-(pyridin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)propylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 
• 1227780-12-2 1-tert-butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-(1-((pyridine-2-yl-methyl)methyl)-1H-1,2,3-triazol-4-yl)butylamino)pyrido[2,3-d]pyrimidin-7-yl)urea 
• 100-70-9 2-Cyanopyridine 
• 1246847-68-6 2-[(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl]pyridine 

Relevant articles and documents

Synthesis, characterization and low temperature self assembling of (η3-allyl)palladium complexes with 2-pyridyl-1,2,3-triazole bidentate ligands. Study of the catalytic activity in Suzuki-Miyaura reaction

The cationic complexes [Pd(η3-C3H 5)(2-((4-propyl-1H-1,2,3-triazol-1-yl)methyl)pyridine)](X) (2: X = BF4-, 3: X = ClO4-), and [Pd(η3-2-CH3-C3Hsu

Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives

A series of phosphinimine ligands were designed and used in the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines and alkynes for the first time. By optimizing the reaction conditions, an efficient catalytic system (CuCl/2-PyCH 2NPtBu3) was developed to give 1-(pyridin-2-yl)-1,2,3-triazole derivatives in moderate to excellent yields (46-98%). This journal is the Partner Organisations 2014.

Synthesis of click-chelator via Cu(I)-catalyzed alkyne-azide cycloaddition

The click-ligands based on 1,2,3-triazole and pyridine unit has been synthesized via Cu(I)-catalyzed alkyne-azide cycloaddition from corresponding organic azides and terminal alkynes. The ligand structure was characterized by NMR, IR and elemental analysis as well as single crystal diffractions. The single crystal structure of the complexes from two different ligands coordinating to Cu(II) and Co(II) ions indicated that the N(2) atom in 1,2,3-triazole unit can act as an efficient donor to metals through the rational molecular design. Copyright