609812-18-2

Basic information

• Product Name: 5-azidomethyl-3-(4-chloro-3-nitro-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyridin-2-yl]-amide
• CAS NO: 609812-18-2
• Molecular Weight: 613.053
• Mol File: 609812-18-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-azidomethyl-3-(4-chloro-3-nitro-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyridin-2-yl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-azidomethyl-3-(4-chloro-3-nitro-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyridin-2-yl]-amide(609812-18-2)
• EPA Substance Registry System: 5-azidomethyl-3-(4-chloro-3-nitro-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-tert-butylsulfamoyl-phenyl)-pyridin-2-yl]-amide(609812-18-2)

Safety Data

• Hazardous Substances Data: 609812-18-2(Hazardous Substances Data)

Upstream product

• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 203512-83-8 2-Amino-5-(2-t-butylaminosulfonyl-phenyl)-pyridine 
• 66399-01-7 2-chloro-5-hydroxyiminomethylnitrobenzene 

Relevant articles and documents

Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors

Factor Xa (fXa) is an important serine protease in the blood coagulation cascade. Inhibition of fXa has emerged as an attractive target for potential therapeutic applications in the treatments of both arterial and venous thrombosis. Herein, we describe a series of non-benzamidine isoxazoline derivatives as fXa inhibitors. The chloroaniline group was found to be the most potent benzamidine mimic in this series. Chloroaniline 1 (ST368) has a Ki value of 1.5 nM against fXa and is highly selective for fXa relative to thrombin and trypsin.