610-81-1 Usage
Description
4-Amino-3-nitrophenol is an aminonitrophenol isomer characterized by its dark red powder form. It is known for its use in various applications due to its unique chemical properties, including its low levels of mutagenic activity.
Uses
Used in Cosmetic Industry:
4-Amino-3-nitrophenol is used as a component in hair dyes and other cosmetic products for its potent human skin sensitizing properties. It is utilized at very low levels to ensure safety while providing the desired effects.
Used in Pharmaceutical Industry:
4-Amino-3-nitrophenol is used as a key intermediate in the synthesis of benzimidazole-based Factor Xa inhibitors, which are trypsin-like serine proteases. These inhibitors play a crucial role in the development of medications targeting various health conditions.
Used in Chemical Research:
4-Amino-3-nitrophenol is employed as a matrix during visible matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). This technique is vital in the analysis and identification of various compounds, making 4-Amino-3-nitrophenol an essential tool in chemical research and development.
Contact allergens
This hair dye used for semipermanent colors seems to
be a rare sensitizer.
Check Digit Verification of cas no
The CAS Registry Mumber 610-81-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 610-81:
(5*6)+(4*1)+(3*0)+(2*8)+(1*1)=51
51 % 10 = 1
So 610-81-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N2O3/c7-5-2-1-4(9)3-6(5)8(10)11/h1-3,9H,7H2
610-81-1Relevant articles and documents
Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation
Wan, Yameng,Zhang, Zhiguo,Ma, Nana,Bi, Jingjing,Zhang, Guisheng
, p. 780 - 791 (2019/01/24)
Novel acylamino-directed relay disubstitutions realize the sequential difunctionalizations of anilides (1) under mild and metal-free conditions for the first time. This [bis(trifluoroacetoxy)iodo]benzene (PIFA) and BF3·Et2O promoted straightforward reaction produces a series of p-acetoxyl- or p-alkoxyl-o-nitro-N-arylamides (2), which are key scaffolds of various drugs, functional materials, and bioactive molecules. The flexibility with respect to the functional groups in these products affords this novel protocol excellent versatility for synthetic applications.