6100-05-6 Usage
Description
Potassium citrate monohydrate is a potassium salt that exists as transparent prismatic crystals or a white, granular powder. It is hygroscopic, odorless, and has a cooling, saline taste. Potassium citrate monohydrate is a sequestrant and buffer with advantageous properties of citric acid without its acid reaction. A 1% solution has a pH of 7.5-9.0 and is soluble in water, with increased solubility at higher temperatures.
Uses
Used in Foods and Beverages:
Potassium citrate monohydrate is used as a buffering, sequestering, or emulsifying agent in the food and beverage industry. It is found in artificially sweetened jelly, certain milk and meat products, processed cheese, puddings, and dietetic foods where sodium is undesirable.
Used in Pharmaceutical Industry:
Potassium citrate tribasic monohydrate (KCTM) is a high-quality pharmacopoeia product that meets the testing specifications of the United States Pharmacopoeia (USP). It can be employed in research and pilot studies, as well as in the formation of aqueous two-phase systems (ATPS) with UCON 50-HB-5100, a random copolymer.
Used in Manufacturing Method of Printed Circuit Boards:
Tripotassium Citrate Monohydrate is utilized in the manufacturing method of printed circuit boards for autonomous vehicles to perform recognition, judgment, determination, and execution.
Used in Citric Acid Production:
Citric acid, a weak organic acid and a commodity chemical, is produced on an industrial scale using crude sugar solutions and strains of Aspergillus niger. Potassium citrate monohydrate plays a role in this production process, as citric acid is widely distributed in plants, animal tissues, and fluids, and is found in higher amounts in various fruits and vegetables, particularly citrus fruits like lemon and limes. Citric acid is mainly used as an acidifier, flavoring agent, and chelating agent in the food and beverage industry.
Production Methods
Potassium citrate is prepared by adding either potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is then filtered and evaporated to dryness to obtain potassium citrate.
Pharmaceutical Applications
Potassium citrate is used in beverages, foods, and oral pharmaceutical
formulations as a buffering and alkalizing agent. It is also used
as a sequestering agent and as a therapeutic agent to alkalinize the
urine and to relieve the painful irritation caused by cystitis.
Biochem/physiol Actions
Potassium citrate can be used to prepare citrate water that supports the survival of streptozotocin (STZ)-diabetic mice. It might reduce the successive stone formation in calcium nephrolithiasis. Potassium citrate serves as an activator for producing activated carbons.
Safety
Potassium citrate is used in oral pharmaceutical formulations and is
generally regarded as a nontoxic and nonirritant material by this
route of administration.
Most potassium citrate safety data relate to its use as a
therapeutic agent, for which up to 10 g may be administered daily,
in divided doses, as a treatment for cystitis. Although there are
adverse effects associated with excessive ingestion of potassium
salts, the quantities of potassium citrate used as a pharmaceutical
excipient are insignificant in comparison to those used therapeutically.
(IV, dog): 0.17 g/kg
storage
Potassium citrate is a stable, though hygroscopic material, and
should be stored in an airtight container in a cool, dry place. It is
deliquescent in moist air.
Purification Methods
It solubility in H2O is 154% and it loses H2O at 180o. [Beilstein 3 III 1091.]
Incompatibilities
Aqueous potassium citrate solutions are slightly alkaline and will
react with acidic substances. Potassium citrate may also precipitate
alkaloidal salts from their aqueous or alcoholic solutions. Calcium
and strontium salts will cause precipitation of the corresponding
citrates. Potassium citrate is incompatible with strong oxidizing
agents.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (oral solutions and suspensions;
topical emulsions and aerosol foams). Included in nonparenteral
medicines (cutaneous foams and emulsions; oral liquids, granules,
mixtures and soluble tablets; topical liquids, emulsions and
mousses) licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 6100-05-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,0 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6100-05:
(6*6)+(5*1)+(4*0)+(3*0)+(2*0)+(1*5)=46
46 % 10 = 6
So 6100-05-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H8O7.3K.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3
6100-05-6Relevant articles and documents
Pickering, S. U.
, p. 1837 - 1851 (1910)
CREATINE HYDROXYCITRIC ACIDS SALTS AND METHODS FOR THEIR PRODUCTION AND USE IN INDIVIDUALS
-
Page/Page column 23, (2008/06/13)
Methods of production for Tricreatine Hydroxycitrate are disclosed. Tricreatine hydroxycitrate can be used as supplemental dietary ingredient for the purposes of reducing adiposity, suppression of appetite, improvement of muscle and exercise performance a
