61152-62-3

Basic information

• Product Name: 4-(3,4-Dihydroxyphenyl)-2-butane
• Synonyms: 4-(3,4-Dihydroxyphenyl)-2-butane;4-(3,4-Dihydroxyphenyl)-2-butanone;4-(3,4-Dihydroxyphenyl)butan-2-one
• CAS NO: 61152-62-3
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• Mol File: 61152-62-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 85.5-86 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• Boiling Point: 220-221 °C(Press: 8 Torr)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.78±0.10(Predicted)
• CAS DataBase Reference: 4-(3,4-Dihydroxyphenyl)-2-butane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-Dihydroxyphenyl)-2-butane(61152-62-3)
• EPA Substance Registry System: 4-(3,4-Dihydroxyphenyl)-2-butane(61152-62-3)

Safety Data

• Hazardous Substances Data: 61152-62-3(Hazardous Substances Data)

Usage

General Description

4-(3,4-Dihydroxyphenyl)-2-butane is a chemical compound that is also known as L-Dopa. It is an amino acid that is produced naturally by the human body and is also used for various medicinal purposes. Its chemical formula is C9H11NO4. L-Dopa serves as a precursor to dopamine, norepinephrine, and epinephrine, which are neurotransmitters responsible for a number of important brain functions such as mood regulation and motor control. Importantly, it is used as a treatment for Parkinson's disease, a neurological condition characterized by the loss of dopamine-producing cells in the brain. It works by replenishing dopamine levels in the patients' brains, thereby easing their symptoms.

Upstream product

• 122-48-5 4-(4-hydroxy-3-methoxyphenyl)-2-butanone 
• 123694-03-1 (E)-4-(3′,4′-dihydroxyphenyl)but-3-en-2-one 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 1080-12-2 Dehydrozingerone 
• 121-33-5 vanillin 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 

Downstream Products

• 61152-58-7 4-(3',4'-dihydroxyphenyl)-2-butanol 
• 63212-99-7 (4E,6E)-1-(3,4-dihydroxyphenyl)-7-phenylhepta-4,6-dien-3-one 
• 79622-76-7 3,4-Dimethoxy-(3'-hydroxybutyl)-benzol 

Relevant articles and documents

Synthesis of Yakuchinone B-Inspired Inhibitors against Islet Amyloid Polypeptide Aggregation

Type 2 diabetes mellitus (T2DM) is associated with pancreatic β-cell dysfunction and insulin resistance. Islet amyloid polypeptide (IAPP) aggregation is found to induce islet β-cell death in T2DM patients. Recently, we demonstrated that yakuchinone B deri

Synthesis and studies of the inhibitory effect of hydroxylated phenylpropanoids and biphenols derivatives on tyrosinase and laccase enzymes

The impaired activity of tyrosinase and laccase can provoke serious concerns in the life cycles of mammals, insects and microorganisms. Investigation of inhibitors of these two enzymes may lead to the discovery of whitening agents, medicinal products, anti-browning substances and compounds for controlling harmful insects and bacteria. A small collection of novel reversible tyrosinase and laccase inhibitors with a phenylpropanoid and hydroxylated biphenyl core was prepared using naturally occurring compounds and their activity was measured by spectrophotometric and electrochemical assays. Biosensors based on tyrosinase and laccase enzymes were constructed and used to detect the type of protein-ligand interaction and half maximal inhibitory concentration (IC50). Most of the inhibitors showed an IC50 in a range of 20–423 nM for tyrosinase and 23–2619 nM for laccase. Due to the safety concerns of conventional tyrosinase and laccase inhibitors, the viability of the new compounds was assayed on PC12 cells, four of which showed a viability of roughly 80% at 40 μM. In silico studies on the crystal structure of laccase enzyme identified a hydroxylated biphenyl bearing a prenylated chain as the lead structure, which activated strong and effective interactions at the active site of the enzyme. These data were confirmed by in vivo experiments performed on the insect model Tenebrio molitur.

Dihydroxyphenyl compounds and glucoside compounds thereof

The present invention is a compound represented by the following formula (1) or (2): where one of R1 and R2 is hydrogen and the other one is hydrogen or glucose residue. The compound is effective for reforming obese constitution, sup