61214-51-5 Usage
Description
BETA-ENDORPHIN HUMAN SYNTHETIC is a synthetically produced peptide hormone that mimics the structure and function of naturally occurring beta-endorphins in the human body. It is composed of 31 amino acid residues and is known for its potent pain-relieving properties. This synthetic version allows for controlled production and consistent quality, making it a valuable asset in medical and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
BETA-ENDORPHIN HUMAN SYNTHETIC is used as a potent pain suppressant for the management of moderate to severe pain. It is particularly effective due to its ability to bind to opioid receptors, particularly of the mu subtype, at both preand post-synaptic nerve terminals. This binding primarily occurs through presynaptic interactions, leading to a reduction in the perception of pain.
Used in Research Applications:
In the field of medical research, BETA-ENDORPHIN HUMAN SYNTHETIC serves as an important tool for studying the mechanisms of pain relief and the role of opioid receptors in the central nervous system. This helps scientists to better understand the processes involved in pain perception and develop new therapeutic strategies for pain management.
Used in Neurological Applications:
BETA-ENDORPHIN HUMAN SYNTHETIC is also utilized in the study and treatment of neurological disorders that involve pain or discomfort. Its ability to bind mu-opioid receptors in the central nervous system allows it to play a role in the management of chronic pain conditions, such as neuropathic pain, and potentially contribute to the development of new treatments for these conditions.
Overall, BETA-ENDORPHIN HUMAN SYNTHETIC is a versatile and valuable compound in the fields of medicine, pharmaceuticals, and research, offering significant potential for pain management and the advancement of our understanding of pain perception and its underlying mechanisms.
Biochem/physiol Actions
β-Endorphin acts as a ligand for both μ and δ opioid receptors in different parts of the brain. It is released in response to painful stimuli and has potent antinociceptive activity. When given supraspinally, this activity is mediated through its action on ε-opioid receptors in brain that results in the release of Met-enkephalin. This activity is also mediated by its interaction with δ2-opioid receptors in the spinal cord. When introduced intrathecally, this function is an outcome of its interaction with μ and κ-opioid receptors in the rat. In autoimmune disorders, the elevated production of cytokines results in the production of β-endorphin, in pituitary and lymphocytes. This acts as a negative regulator of antibody production, and is thus, implicated in autoimmune diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 61214-51-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,2,1 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 61214-51:
(7*6)+(6*1)+(5*2)+(4*1)+(3*4)+(2*5)+(1*1)=85
85 % 10 = 5
So 61214-51-5 is a valid CAS Registry Number.
InChI:InChI=1/C158H251N39O46S/c1-17-84(9)126(153(237)182-102(44-29-34-65-163)137(221)186-112(74-118(166)206)142(226)171-86(11)131(215)183-110(73-94-48-52-96(204)53-49-94)146(230)177-99(41-26-31-62-160)135(219)175-98(40-25-30-61-159)134(218)170-78-122(210)173-106(158(242)243)56-59-124(213)214)193-154(238)127(85(10)18-2)192-132(216)87(12)172-143(227)113(75-119(167)207)185-136(220)100(42-27-32-63-161)178-147(231)111(72-92-38-23-20-24-39-92)184-144(228)107(68-81(3)4)188-155(239)129(89(14)201)195-152(236)125(83(7)8)191-148(232)108(69-82(5)6)187-151(235)116-45-35-66-197(116)157(241)130(90(15)202)196-140(224)103(54-57-117(165)205)179-149(233)114(79-198)189-138(222)101(43-28-33-64-162)176-139(223)104(55-58-123(211)212)180-150(234)115(80-199)190-156(240)128(88(13)200)194-141(225)105(60-67-244-16)181-145(229)109(71-91-36-21-19-22-37-91)174-121(209)77-168-120(208)76-169-133(217)97(164)70-93-46-50-95(203)51-47-93/h19-24,36-39,46-53,81-90,97-116,125-130,198-204H,17-18,25-35,40-45,54-80,159-164H2,1-16H3,(H2,165,205)(H2,166,206)(
61214-51-5Relevant articles and documents
Nicotinoyl peptide derivatives and cosmetic composition comprising the same
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, (2012/03/11)
The present invention relates to nicotinoyl peptide derivatives, wherein neuropeptides are connected to nicotinic acid, and a cosmetic composition comprising the same. The peptide derivatives according to the present invention have good collagen generation and anti-inflammatory activities to show an excellent anti-wrinkle effect, little cytotoxicity, water-solubility, and good stability during long-term storage. Therefore, they can be effectively used for preparing an anti-aging cosmetic composition.
