612499-61-3

Basic information

• Product Name: Benzeneethanamine, N-(3-bromopropyl)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-b-phen yl-
• CAS NO: 612499-61-3
• Molecular Formula: C25H24BrClF3N
• Molecular Weight: 510.824
• Mol File: 612499-61-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzeneethanamine, N-(3-bromopropyl)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-b-phen yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanamine, N-(3-bromopropyl)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-b-phen yl-(612499-61-3)
• EPA Substance Registry System: Benzeneethanamine, N-(3-bromopropyl)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-b-phen yl-(612499-61-3)

Safety Data

• Hazardous Substances Data: 612499-61-3(Hazardous Substances Data)

Upstream product

• 93118-03-7 2-chloro-3-trifluoromethylbenzaldehyde 
• 3963-62-0 2,2-Diphenylethylamine 
• 405911-35-5 N-(2,2-diphenylethyl)-N-(2-chloro-trifluoromethylbenzyl)amine 
• 106-94-5 propyl bromide 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 848086-74-8 5{3-[(chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-3,4-dihydro-2H-quinoline-1-carboxylic acid ter-butyl ester 
• 848086-81-7 (5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-carbamic acid tert-butyl ester 
• 848086-72-6 5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid methyl ester 
• 847990-40-3 (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(1H-indol-4-yloxy)-2-methyl-propyl]-amine 
• 405911-26-4 methyl 2-{3-[3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}-(2,2-diphenylethyl)-amino)-propoxy]phenyl}acetate 

Relevant articles and documents

LXR AGONISTS AND USES THEREOF

This invention features compounds that modulate the activity of liver X receptors, pharmaceutical compositions including the compounds of the invention, and methods of utilizing those compositions for modulating the activity of liver X receptors in the treatment of cancer.

Synthesis and SAR of potent LXR agonists containing an indole pharmacophore

A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXRα will be disclosed.

COMPOUNDS AND METHODS

Disclosed are compounds and pharmaceutically acceptable salts thereof, useful as LXR agonists.