61323-28-2Relevant articles and documents
IAP ANTAGONISTS AND THEIR THERAPEUTIC APPLICATIONS
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Page/Page column 60, (2021/11/06)
The present invention relates to Formula I. compounds including their isomers, tautomeric forms and rotamers, salts together with their manufacturing process and their pharmacological use alone or in combination with other active ingredients for the treatment of cell and tissue malignances caused diseases, including uncontrolled cell or tissue growth, proliferation and cancer.
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists
Nagashima, Shinya,Matsushima, Yuji,Hamaguchi, Hisao,Nagata, Hiroshi,Kontani, Toru,Moritomo, Ayako,Koshika, Tadatsura,Takeuchi, Makoto
, p. 3478 - 3487 (2014/06/23)
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.
ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF
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Page/Page column 80, (2010/05/13)
Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.