61403-29-0

Basic information

• Product Name: Acetamide, N-(2-ethynylphenyl)-
• Synonyms: 2-acetamidophenylacetilene;N-acetyl-o-ethynylaniline;N-acetyl-2-ethynylaniline;2-ethynylacetanilide
• CAS NO: 61403-29-0
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Mol File: 61403-29-0.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(2-ethynylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(2-ethynylphenyl)-(61403-29-0)
• EPA Substance Registry System: Acetamide, N-(2-ethynylphenyl)-(61403-29-0)

Safety Data

• Hazardous Substances Data: 61403-29-0(Hazardous Substances Data)

Upstream product

• 67177-79-1 phenylnitroacetylene 
• 19591-17-4 o-iodoacetanilide 
• 74-86-2 acetylene 
• 614-76-6 N-acetyl-2-bromoaniline 
• 103529-16-4 2-[(trimethylsilyl)ethynyl]aniline 
• 615-43-0 2-iodophenylamine 
• 52670-38-9 2-ethynylaniline 
• 75-36-5 acetyl chloride 
• 110598-59-9 N-acetyl-2-<(trimethylsilyl)ethynyl>aniline 
• 108-24-7 acetic anhydride 
• 1173504-88-5 N-(2-((triisopropylsilyl)ethynyl)phenyl)acetamide 
• 103-84-4 Acetanilid 

Downstream Products

• 30405-79-9 bis-(2-acetylamino-phenyl)-butadiyne 
• 148550-53-2 2-[Acetyl-(2-ethynyl-phenyl)-amino]-pyrimidine-5-carboxylic acid ethyl ester 
• 1009034-79-0 C₁₆H₁₉NOSi 
• 1009034-77-8 C₁₄H₁₃NO 
• 1009034-75-6 N-(2-ethynylphenyl)-N-prop-2-ynyl-acetamide 
• 120-72-9 indole 
• 91-56-5 indole-2,3-dione 
• 1421479-94-8 C₁₃H₁₃NO₂ 

Relevant articles and documents

DISUBSTITUTED ALKYNE DERIVATIVES

The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Enantioselective A3-Coupling Reaction Employing Chiral CuI-i PrpyboxdiPh/ N-Boc-(l)-Proline Complex under Cooperative Catalysis: Application in the Synthesis of (Indol-2-yl)methanamines

An efficient route to enantioenriched propargylamines via a three-component alkynylation reaction using cooperative catalysis with a CuI-iPrpyboxdiPh complex and N-Boc-(l)-proline has been accomplished. A variety of functionalized amines, aldehydes, and 2-ethynyl anilines were reacted smoothly at ambient temperature to furnish a wide range of propargylamines in high yields (up to 94%) and excellent enantioselectivities (up to 98% ee). Synthetic utility of the methodology has been demonstrated by transforming the products into various synthetically useful intermediates. Finally, propargylamines were transformed into biologically important (indol-2-yl)methanamines over two steps in good yields (up to 88%) with an excellent level of enantioselectivities (up to 95%).

PtCl4-catalyzed cyclization of N-acetyl-2-alkynylanilines: A mild and efficient synthesis of N-acetyl-2-substituted indoles

An efficient synthesis of N-acetyl-2-substituted indole derivatives via direct intramolecular hydroamination of N-acetyl-2-alkynylaniline derivatives was developed. The reaction could be applied to a wide range of substrates employing only 1–2 mol% of PtCl4 as the catalyst to furnish the desired indole products in moderate to excellent yields. The current protocol is efficient, reliable and scalable, and could serve as an important tool for convenient and rapid access to this important class of N-heterocyclic skeleton from readily available substrates.