6142-65-0

Basic information

• Product Name: 2-(4-bromophenyl)cyclopropanecarboxylic acid
• CAS NO: 6142-65-0
• Molecular Formula: C₁₀H₉BrO₂
• Molecular Weight: 241.0813
• Mol File: 6142-65-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 364.5°C at 760 mmHg
• Flash Point: 174.2°C
• Density: 1.652g/cm³
• Vapor Pressure: 5.95E-06mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 2-(4-bromophenyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)cyclopropanecarboxylic acid(6142-65-0)
• EPA Substance Registry System: 2-(4-bromophenyl)cyclopropanecarboxylic acid(6142-65-0)

Safety Data

• Hazardous Substances Data: 6142-65-0(Hazardous Substances Data)

Usage

Molecular Weight

335.2

Structure

A cyclopropane ring (C3H5) attached to a phenyl group (C6H5) with a bromine atom (Br) in position 4, and a carboxylic acid group (COOH) attached to the cyclopropane ring.

+ Appearance

White or off-white crystalline solid

+ Melting Point

154-156°C

+ Boiling Point

Not readily available due to its stability

+ Solubility

Slightly soluble in water, soluble in organic solvents like ethanol, methanol, and acetone.

+ Reactivity

Can undergo reactions like esterification, amide formation, and halogenation.

+ Stability

Stable under normal temperature and pressure, but may decompose upon exposure to heat or strong oxidizing agents.

Biological Activity

+ Potential pharmacological and biological activities, making it an interesting target for drug discovery and medicinal chemistry research.

Applications

+ Synthesis of various pharmaceuticals and biologically active molecules
+ Building block in the preparation of diverse organic compounds
+ Versatile chemical with potential use in various applications.

Upstream product

• 2137065-16-6 (cis)-2-(4-bromophenyl)cyclopropanecarboxylic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 1759-53-1 cyclopropanecarboxylic acid 
• 53582-00-6 ethyl trans-2-(p-bromophenyl)-1-cyclopropanecarboxylate 
• 134198-10-0 racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide 
• 1885-28-5 γ-(4-bromophenyl)-γ-butyrolactone 
• 100115-96-6 4-Chlor-4-(4-brom-phenyl)-buttersaeureethylester 
• 1122-91-4 4-bromo-benzaldehyde 
• 24393-53-1 ethyl (E)-3-(4-bromophenyl)-2-propenoate 
• 1200-07-3 trans-4-bromocinnamic acid 
• 2039-82-9 1-bromo-4-ethenyl-benzene 

Downstream Products

• 1123620-89-2 (1S,2S)-2-(4-bromophenyl)cyclopropanecarboxylic acid 
• 31501-85-6 (R,R)-2-(4-bromophenyl)cyclopropanecarboxylic acid 
• 1418287-95-2 (±)-trans-O-tert-butyl-N-(2-(4-bromophenyl)cyclopropyl)carbamate 
• 1332345-01-3 C₁₀H₉BrO₂*C₁₂H₁₃N 
• 1240914-03-7 4-{(1S, 2S)-2-[((R)-4-cyclobutyl-2-methylpiperazin-1-yl)carbonyl]-cyclopropyl}-benzamide 
• 1241093-84-4 (1S, 2S)-2-(4-Carbamoyl-phenyl)-cyclopropanecarboxylic acid 
• 1240914-95-7 ((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone 
• 1240914-98-0 4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile 
• 1240914-90-2 (1S,2S)-2-(4-cyano-phenyl)-cyclopropanecarboxylic acid 
• 1240914-92-4 C₁₁H₁₀NO₃^(1-)*Na⁽¹⁺⁾ 

Relevant articles and documents

NOVEL LYSOPHOSPHATIDIC ACID DERIVATIVE

PROBLEM TO BE SOLVED: To provide a compound that specifically activates an LPA4 receptor, and a pharmaceutical composition containing the same. SOLUTION: This invention relates to a novel lysophosphatidic acid derivative that has an agonistic action on an LPA4 receptor and is useful for the prevention and/or treatment of a disease with angiodysplasia caused by the LPA4 receptor, or a disease associated with angiopathy, or symptoms associated therewith. This invention also relates to a pharmaceutical composition containing the lysophosphatidic acid derivative. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

Synthesis and in vitro evaluation of novel N-cycloalkylcarbamates as potential cholinesterase inhibitors

Abstract: This present paper describes the preparation and characterization of a series of O-substituted N-cycloalkylcarbamate derivatives. These compounds were tested as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All studied carbamates exhibited moderate inhibitory activity of both cholinesterases with values of IC50 in the range of 36.1–78.6?μM for AChE and 9.8–215.4?μM for BChE, respectively. These values are comparable with those values of inhibition obtained with the established drug rivastigmine. The cytotoxicity of all carbamates was evaluated using standard in vitro test with Jurkat cells. Many of the studied carbamates can be considered as promising compounds for potential medicinal applications with regard to their inhibitory activity as well as negligible cytotoxicity.