61440-60-6

Basic information

• Product Name: 3-(4-chlorophenyl)propyl methanesulfonate
• Synonyms: 3-(4-chlorophenyl)propyl methanesulfonate;-(4-chlorophenyl)propyl methanesulfonate
• CAS NO: 61440-60-6
• Molecular Formula: C₁₀H₁₃ClO₃S
• Molecular Weight: 248.73
• Mol File: 61440-60-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-chlorophenyl)propyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)propyl methanesulfonate(61440-60-6)
• EPA Substance Registry System: 3-(4-chlorophenyl)propyl methanesulfonate(61440-60-6)

Safety Data

• Hazardous Substances Data: 61440-60-6(Hazardous Substances Data)

Usage

Description

3-(4-chlorophenyl)propyl methanesulfonate, also known as 3-(4-Chlorophenyl)propyl Mesylate, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its chemical structure, which includes a methanesulfonate group attached to a 3-(4-chlorophenyl)propyl moiety. This unique structure endows it with specific reactivity and properties that make it valuable in the development of certain medications.

Uses

Used in Pharmaceutical Synthesis:
3-(4-chlorophenyl)propyl methanesulfonate is used as a key reagent in the synthesis of Tiprolisant, a medication specifically designed to treat excessive daytime sleepiness in adults with narcolepsy. Its role in the synthesis process is crucial, as it contributes to the formation of the final drug molecule, which targets and modulates the histamine H3 receptor, thereby reducing the symptoms of narcolepsy.

Upstream product

• 6282-88-8 3-(p-chlorophenyl)propanol 
• 124-63-0 methanesulfonyl chloride 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 

Downstream Products

• 362665-56-3 pitolisant 
• 294863-03-9 1-[(R)-1-(tert-butyldimethylsilyloxy)-4-[6-(3-(4-chlorophenyl)propoxy)indol-1-yl]-2-butyl]imidazole-4-carboxamide 
• 294863-07-3 1-{(R)-1-(tert-butyldimethylsilyloxy)-4-[5-(3-(4-chlorophenyl)propoxy)-1-methylindol-3-yl]-2-butyl}imidazole-4-carboxamide 
• 175219-66-6 S-[3-(4-chlorophenyl)propyl]ethanethioate 
• 756836-89-2 4-carboxy-2-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one 
• 61440-61-7 ethyl 4-[3-(p-chlorophenyl)propylamino]benzoate 
• 96089-75-7 4-[bis[3-(p-chlorophenyl)propyl]amino]benzoic acid, ethyl ester 

Relevant articles and documents

DEUTERATED PITOLISANT

This invention also provides compound of Formula (I) including pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier. This invention also provides the use of such compounds and compositions in methods o

A new series of estrogen receptor modulators that display selectivity for estrogen receptor β

A series of 1,3,5-triazine-based estrogen receptor (ER) modulators that are modestly selective for the ERβ subtype are reported. Compound 1, which displayed modest potency and selectivity for ERβ vs ERα, was identified via high-throughput screening utiliz

Arylalkylaminobenzoic acids

This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.