61466-44-2

Basic information

• Product Name: (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE
• Synonyms: 4-(2-HYDROXYBENZOYL)-1-PHENYL-PYRAZOLE;2-HYDROXYPHENYL 1-PHENYL-1 H-PYRAZOL-4-YL KETONE;(2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE;1-PHENYL-4(2-HYDROXYBENZOYL)PYRAZOLE;TIMTEC-BB SBB001017
• CAS NO: 61466-44-2
• Molecular Formula: C₁₆H₁₂N₂O₂
• Molecular Weight: 264.28
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 61466-44-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 108-110 °C(lit.)
• Boiling Point: 421.9°C at 760 mmHg
• Flash Point: 209°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 1.02E-07mmHg at 25°C
• Refractive Index: 1.639
• PKA: 7.52±0.30(Predicted)
• CAS DataBase Reference: (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE(61466-44-2)
• EPA Substance Registry System: (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE(61466-44-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 61466-44-2(Hazardous Substances Data)

Usage

Description

(2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE, also known as 2-Hydroxyphenyl 1-phenyl-1H-pyrazol-4-yl ketone, is a heterocyclic building block derived from the fusion of a phenyl ring with a pyrazolone moiety. (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE exhibits unique chemical and physical properties due to its heterocyclic structure, making it a versatile molecule for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
(2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its heterocyclic structure allows for the development of new drugs with potential therapeutic applications, such as anti-inflammatory, analgesic, and antimicrobial agents.
Used in Chemical Synthesis:
In the field of organic chemistry, (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE serves as a valuable building block for the creation of more complex molecules. Its reactivity and structural diversity make it an ideal candidate for the synthesis of novel compounds with potential applications in various industries, such as materials science, agrochemistry, and pharmaceuticals.
Used in Material Science:
(2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE can be utilized in the development of advanced materials with unique properties. Its heterocyclic structure can be exploited to design and synthesize new materials with improved mechanical, electronic, or optical properties, which can be applied in various fields, such as electronics, sensors, and energy storage devices.
Used in Dye and Pigment Industry:
Due to its chromophoric properties, (2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE can be employed in the synthesis of dyes and pigments with specific color characteristics. These dyes and pigments can be used in various applications, such as textiles, plastics, inks, and coatings, to impart desired color and aesthetic properties.
Used in Research and Development:
(2-HYDROXYPHENYL)(1-PHENYL-1H-PYRAZOL-4-YL)METHANONE is also used as a research tool in academic and industrial laboratories. Its unique structure and reactivity make it an attractive candidate for studying various chemical reactions and mechanisms, as well as for the development of new synthetic methods and strategies.

InChI:InChI=1/C16H12N2O2/c19-15-9-5-4-8-14(15)16(20)12-10-17-18(11-12)13-6-2-1-3-7-13/h1-11,19H

Upstream product

• 61424-75-7 3-formylchromone 3-oxime 
• 59-88-1 phenylhydrazine hydrochloride 
• 21601-26-3 3-((2-phenylhydrazono)methyl)-4H-chromen-4-one 
• 57443-91-1 3-<(4-Oxo-4H-1-benzopyran-3-yl)-methylene>pentan-2,4-dione 
• 17422-79-6 2-(4-oxo-4H-1-benzopyran-3-yl)-1,3-dioxolane 
• 17422-74-1 3-Formylchromone 
• 100-63-0 phenylhydrazine 
• 91546-66-6 3-N,N-dimethylhydrazonomethyl-4(H)-oxo-<1>benzopyran 
• 132326-55-7 ethyl 2-cyano-3-(4H-1-benzoypyran-4-one-3-yl)-acrylate 
• 67733-35-1 [(4-oxo-4H-chromen-3-yl)methylidene]-propanedinitrile 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 68430-96-6 (2-acetoxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone 
• 93065-69-1 ethyl 2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetate 
• 154405-45-5 ethyl 3-hydroxy-3-(2-hydroxyphenyl)-3-(1-phenylpyrazol-4-yl)propanoate 
• 74990-94-6 phenyl hydrazone de l'(hydroxy-2 benzoyl)-4 phenyl-1 pyrazole 
• 112030-41-8 2-benzoyl-3-(1-phenyl-1H-pyrazol-4-yl)benzofuran 
• 118545-62-3 3-(4-Chloro-phenyl)-4-(1-phenyl-1H-pyrazol-4-yl)-chromen-2-one 
• 118545-58-7 3-phenyl-4-(1-phenylpyrazol-4-yl)coumarin 
• 118545-66-7 3-(4-Methoxy-phenyl)-4-(1-phenyl-1H-pyrazol-4-yl)-chromen-2-one 
• 154405-48-8 4-(2-hydroxybenzoyl)-1-phenylhydrazole oxime 
• 1134-50-5 4-carboxy-1-phenylpyrazole 
• 154405-51-3 2-(1-phenylpyrazol-4-yl)amidophenol 
• 154405-46-6 ethyl 3-(2-hydroxyphenyl)-3-(1-phenylpyrazol-4-yl)-2-propenoate 
• 93065-36-2 3-(1-Phenyl-1H-pyrazol-4-yl)benzofuran-2-carboxylic acid 
• 1031730-04-7 4-(1-phenyl-1H-pyrazol-4-yl)-3-vinylcoumarin 

Relevant articles and documents

One pot synthesis of 4-(2-hydroxybenzoyl)-pyrazoles from 3- formylchromones under microwave irradiation in solvent free conditions

The synthesis of 4-(2-hydroxybenzoyl)pyrazoles (3) was achieved in a single step by the reaction of 3-formylchromones (1) with Phenylhydrazine or Tosylhydrazine under microwave irradiation without a solvent.

In vitro cytotoxicity of hydrazones, pyrazoles, pyrazolo-pyrimidines, and pyrazolo-pyridine synthesized from 6-substituted 3-formylchromones

Pyrazoles 4a-f, hydrazones 5a-c and 6a-c, pyrazolo[1,5-a]pyrimidines 7a, b, and pyrazolo[3,4-b]pyridine 8 were prepared in good yields (80-95%) from the reaction of 6-substituted (H, Me, F) 3-formylchromones 1a-c with N-substituted hydrazines 2a-c and ami

Benzopyrans: Part XXIX - Reactions of some simple condensates of 4-oxo-4H-1-benzopyran-3-carboxaldehyde with nitrogen nucleophiles

The chromone 2, derived from the title aldehyde 1, gives the pyrazole 8 (R3 = Ph) with phenylhydrazine whereas 5 gives with H2NNHR3 (R3 =H and Ph) the pyridine derivatives (9).Hydroxylamine converts the chromones 2-4 into pyridine-1-oxides (13-15), respectively.The reaction of 1 with ethyl glycinate in the presence of pyridine affords the pyrroles 20 and 21, the former (20) being detected in the product mixture derived from 4 and ethyl glycinate.