614730-96-0

Basic information

• Product Name: TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;4-Cyano-4-(hydroxymethyl)-1-piperidinecarboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-cyano-4-(hydroxyMethyl)-, 1,1-diMethylethyl ester;1-BOC-4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE;2-Methyl-2-propanyl 4-cyano-4-(hydroxyMethyl)-1-piperidinecarboxylate;tert-butyl 4-cyano-4-(hydroxyMethyl);tert-Butyl 4-cyano-4-(hydroxymethyl)piperidin-1-carboxylate
• CAS NO: 614730-96-0
• Molecular Formula: C₁₂H₂₀N₂O₃
• Molecular Weight: 240.301
• Mol File: 614730-96-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 382.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.14
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE(614730-96-0)
• EPA Substance Registry System: TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE(614730-96-0)

Safety Data

• Hazardous Substances Data: 614730-96-0(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 4-Cyano-4-(Hydroxymethyl)piperidine-1-carboxylate is a synthetic compound with the molecular formula C15H23N3O3. It is a piperidine derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical has a tert-butyl group attached to the piperidine ring, as well as a cyano and hydroxymethyl group, making it useful in the creation of various medicinal and agricultural products. Tert-Butyl 4-Cyano-4-(Hydroxymethyl)piperidine-1-carboxylate is known for its stability and potential for diverse applications in the chemical industry.

InChI:InChI=1S/C12H20N2O3/c1-11(2,3)17-10(16)14-6-4-12(8-13,9-15)5-7-14/h15H,4-7,9H2,1-3H3

Upstream product

• 162686-53-5 C₁₄H₁₈N₂O 
• 24424-99-5 di-tert-butyl dicarbonate 
• 50-00-0 formaldehyd 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 1016258-66-4 1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate 
• 4395-98-6 4-cyanopiperidine 

Downstream Products

• 929302-00-1 tert-butyl 4-cyano-4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate 
• 1416984-93-4 N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichlorobenzamide 
• 1416984-76-3 tert-butyl 4-(aminomethyl)-4-(hydroxymethyl)piperidine-1-carboxylate 
• 1416984-84-3 tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-(hydroxymethyl)piperidine-1-carboxylate 
• 1416984-94-5 3,5-dichloro-N-((4-(hydroxymethyl)piperidin-4-yl)methyl)benzamide hydrochloride 
• 1207178-51-5 C₁₂H₂₁N₃O₂ 

Relevant articles and documents

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula I ( I ), or a pharmaceutically acceptable salt thereof, is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

Synthesis of 1,4- and 1,4,4-substituted piperidines for the inhibition of neuronal T-type Ca2+ channels and mitigation of neuropathic pain in mice

A dysregulation in function of neuronal low-voltage-activated T-channel causes neuropathic pain. A group of ten 1,4-disubstituted and 1,4,4-trisubstituted piperidines were synthesized through short sequences of reactions from 4-cyanopiperidine, which may potentially produce a library of analogs. Inhibitions of T-channel in rat dorsal root ganglion neurons and/or Cav3.2 channel in human embryonic kidney-293 cells were screened, and subsequent analgesic effects and inhibition of seizure in pentylenetetrazole-induced seizure mouse model were examined. The two most promising piperidine molecules showed analgesic effects in rat model using a spared nerve injury protocol. One displayed a long withdrawal latency in response to thermal stimulation, and an 80% increase in mechanical threshold assessment studies.

ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES

The present invention is directed towards new chemical entities which primarily inhibit the human T-type calcium channels and differentially modulate other key ion channels to control cell excitability, and abnormal neuronal activity particularly involved in the development and maintenance of persistent or chronic pain, and / or neurological disorders. These novel compounds are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which these ion channels are involved. The invention is also directed towards pharmaceutical formulations comprising these compounds and the uses of these compounds.