61489-71-2

Basic information

• Product Name: HUMAN MENOPAUSAL GONADOTROPHIN
• Synonyms: MENOPAUSAL GONADOTROPHIN, HUMAN URINE;MENOTROPIN;HMG;HUMAN MENOPAUSAL GONADOTROPHIN;HUMAN MENOPAUSAL GONADOTROPIN;GONADOTROPIN;GONADOTROPIN, HUMAN MENOPAUSAL URINE;gonadotropin,humanmenopausal
• CAS NO: 61489-71-2
• Molecular Formula: C9H18O
• Molecular Weight: 142.23862
• Product Categories: Peptides
• Mol File: 61489-71-2.mol
• Article Data: 0

Chemical Properties

• Appearance: White or off-white powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: HUMAN MENOPAUSAL GONADOTROPHIN(CAS DataBase Reference)
• NIST Chemistry Reference: HUMAN MENOPAUSAL GONADOTROPHIN(61489-71-2)
• EPA Substance Registry System: HUMAN MENOPAUSAL GONADOTROPHIN(61489-71-2)

Safety Data

• Hazard Codes: B
• WGK Germany: 3
• RTECS: MT6425640
• Hazardous Substances Data: 61489-71-2(Hazardous Substances Data)

Usage

Description

HUMAN MENOPAUSAL GONADOTROPHIN is a gonad-stimulating hormone derived from the urine of postmenopausal women. It is used to stimulate the growth and maturation of ovarian follicles, making it a valuable tool in fertility treatments and assisted reproductive technologies.

Uses

Used in Fertility Treatments:
HUMAN MENOPAUSAL GONADOTROPHIN is used as a gonad-stimulating hormone for the treatment of infertility. It helps to stimulate the growth and maturation of ovarian follicles, increasing the chances of successful fertilization and pregnancy.
Used in Assisted Reproductive Technologies:
HUMAN MENOPAUSAL GONADOTROPHIN is used as a gonad-stimulating hormone in assisted reproductive technologies such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). It helps to stimulate the growth and maturation of ovarian follicles, increasing the chances of obtaining viable oocytes for fertilization.
Used in Animal Reproduction Research:
HUMAN MENOPAUSAL GONADOTROPHIN is used as a gonadotropin supplement in pre-incubated maturation medium for the culture of bovine cumulus oocyte complexes (COCs). It is used to study the effects of multiple freeze-thawing of bovine epididymal sperm on in vitro development of embryos, contributing to advancements in animal reproduction research.

Biochem/physiol Actions

Gonadotropin interacts with members of the GPCR (G-protein coupled receptor family), and upon activation they induce adenylyl cyclase. This hormone is synthesized in male reproductive tract and has high concentration in semen, especially the a subunit. This subunit is linked with spermatogenesis, and lower levels are present in males with aberrant semen quality.

Clinical Use

Menotropins are a natural product that is obtained from the urine of postmenopausal women and then biologically standardized (international units [IU]) for FSH and LH activities in an approximate ratio of 1:1. Menotropins are used in males with primary (hypothalamic) or secondary (pituitary) hypogonadism to stimulate spermatogenesis, providing they have been treated previously with human chorionic gonadotropin (hCG; a peptide hormone of placental origin that has activity very similar to LH) to effect masculinization (increased testosterone inducing ovulation in women who are having difficulty ovulating as a result of either hypothalamic or pituitary hormonal dysfunction. The menotropins are given for 7 to 12 days, and after clinical evaluation (via ultrasound) indicates the presence of a mature follicle, a single dose of hCG is given to simulate the typical LH surge that normally triggers ovulation. Also, women use the combination of menotropins and hCG to promote the development of multiple follicles when they are participating in an IVF program requiring the recruitment of follicles.