615-71-4Relevant articles and documents
Synergistic effect from Lewis acid and the Ni-W2C/AC catalyst for highly active and selective hydrogenation of aryl nitro to aryl amine
Zhao, Zhongkui,Yang, Hongling,Li, Yu
, p. 22669 - 22677 (2014)
This work presents a facile approach for clean and chemoselective synthesis of various functionalized arylamines from their corresponding substituted nitroarenes through the unexpected synergistic effect of a Lewis acid and the Ni-W2C/AC catalyst, affording almost 100% arylamine yield. The results challenge the long-held axiom that the combination of Lewis acid and hydrogenation catalyst mainly enhances the transformation of nitrobenzene (NB) to p-aminophenol via Bamberger rearrangement of the formed intermediate phenylhydroxylamine (PHA) under catalytic hydrogenation conditions. X-ray diffraction (XRD) and FT-IR spectroscopy were employed to reveal the relationship between catalyst nature and catalytic performance, and a plausible reaction mechanism is also proposed. Reaction results demonstrate that the FeCl3-Ni-W2C/AC catalytic system shows comparable catalytic performance towards precious metals for chemoselective reduction of various aromatic nitro compounds, affording 100% yield for all substrates involved in this work (99.5% of isolated yield for model substrate). Moreover, it can be found that the catalyst could be easily recovered by filtration and recycled without visible loss of its catalytic activity. Therefore, the developed FeCl3-Ni-W2C/AC catalytic system in this work can be considered as a practical candidate for clean and highly-efficient synthesis of diverse functionalized arylamines. We believe this approach can be extended to the other hydrogenation reactions. This journal is the Partner Organisations 2014.
Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
Bian, Yuanyuan,Chen, Yadong,Hong, Qianqian,Jiang, Fei,Kong, Bo,Li, Hongmei,Lu, Tao,Ma, Yu,Ran, Ting,Tang, Weifang,Wang, Cong,Yang, Na,Zhang, Zhimin,Zheng, Wan,Zhu, Jiapeng,Zhu, Zhaohong
, (2021/11/03)
As epigenetic readers, bromodomain and extra-terminal domain (BET) family proteins bind to acetylated-lysine residues in histones and recruit protein complexes to promote transcription initiation and elongation. Inhibition of BET bromodomains by small molecule inhibitors has emerged as a promising therapeutic strategy for cancer. Herein, we describe our efforts toward the discovery of a novel series of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as BET inhibitors. Intensive structural modifications led to the identification of compound 35f as the most active inhibitor of BET BRD4 with selectivity against BET family proteins. Further biological studies revealed that compound 35f can arrest the cell cycle in G0/G1 phase and induce apoptosis via decreasing the expression of c-Myc and other proteins related to cell cycle and apoptosis. More importantly, compound 35f showed favorable pharmacokinetic properties and antitumor efficacy in MV4-11 mouse xenograft model with acceptable tolerability. These results indicated that BET inhibitors could be potentially used to treat hematologic malignancies and some solid tumors.
Ionic liquid covered iron-oxide magnetic nanoparticles decorated zeolite nanocomposite for excellent catalytic reduction and degradation of environmental toxic organic pollutants and dyes
Alarifi, Saud,Ali, Daoud,Arumugam, Vasanthakumar,Chandrasekaran, Murugesan,Dass, Avitha,Gao, Yanan,Gengan, Robert M,Moodley, Kandasamy G
, (2021/09/20)
Ionic liquid 2′,3′-epoxypropyl-N-methyl-2-oxopyrrolidinium salicylate ([EPMpyr][SAL]) IL, bonded iron oxide magnetic nanoparticles (MNP) with zeolite modified nanocomposite (IL/MNP/Zeo) was synthesized. This nanocomposite was characterized by micro and macroscopic techniques, namely, Fourier transform infrared spectroscopy (FTIR), x-ray powder diffraction (XRD), scanning electron microscope (SEM), energy dispersive x-ray spectrometry (EDX), transmission electron microscopy (TEM), thermogravimetry and differential scanning calorimetry (TGA&DSC). These techniques have been used to reveal the overall physical properties including functional groups which are present, crystalline nature, morphology, elemental identifications and thermal stability of the nanocomposite respectively. In this case, ionic liquid (IL) and iron oxide magnetic nanoparticles (MNP) were synthesized and characterized. Both IL and MNPs contributed to enhancing the binding property and thermal stability of the nanocomposite. This novel nanocomposite acts as an excellent catalyst for the reduction of several nitroanilines, namely, 2-nitroaniline, 3-nitroaniline, 4-nitroaniline, Nitrophenyl diamine and dyes (Methylene blue and Allura red). In this investigation, time-dependent UV–vis spectroscopy was used to monitor the reduction reactions. Furthermore, the catalyst was removed after completion of the reaction, using an external magnet; then purified and recycled for further reactions with negligible loss of activity. In addition, these reduction reactions are obtained in an aqueous medium which makes them more economical, eco-friendly and easy to handle. This type of research is very helpful in environmental protection; especially the pollution of natural water resources from industrial wastewater.
Palladium Nanoparticles on a Creatine-Modified Bentonite Support: An Efficient and Sustainable Catalyst for Nitroarene Reduction
Gholinejad, Mohammad,Rasouli, Zahra,Najera, Carmen,Sansano, José M.
, p. 1122 - 1129 (2019/09/06)
Creatine as the nitrogen-rich, green and cheap compound is used for modification of natural bentonite and the resulting material is employed for the stabilization of Palladium nanoparticles having an average diameter of 3 nm. This new material bento-crt@Pd is characterized using different techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), solid state UV-vis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and energy-dispersive X-ray spectroscopy (EDX). This green catalyst promotes efficient reduction of aromatic nitro compounds in aqueous media. By using this catalyst nitroarenes having electron donating as well as electron withdrawing groups were reduced efficiently to their corresponding amines at room temperature. The catalyst can be recycled seven times and the reused catalyst was characterized by TEM and XPS.
