61563-33-5 Usage
General Description
8-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a complex chemical compound with potential applications in organic chemistry and pharmaceuticals. Its unique structure, featuring a mix of hydrogen, carbon, chlorine, and nitrogen atoms make it a potential substrate for creating more complex structures and compounds. The additional hydrochloride group can enhance its reactivity and stability in acidic conditions. Like many chemical compounds, it needs to be handled with care and appropriately stored due to its potentially reactive properties. It's crucial in various research fields, and its specific properties can make it highly valuable for experiments and synthesis of other chemicals. As with all chemicals, proper safety procedures must be followed when handling this substance.
Check Digit Verification of cas no
The CAS Registry Mumber 61563-33-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,5,6 and 3 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 61563-33:
(7*6)+(6*1)+(5*5)+(4*6)+(3*3)+(2*3)+(1*3)=115
115 % 10 = 5
So 61563-33-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H10ClN.ClH/c10-9-3-1-2-7-4-5-11-6-8(7)9;/h1-3,11H,4-6H2;1H
61563-33-5Relevant articles and documents
Synthesis and further transformations of 8-chloro-3,4-dihydroisoquinoline
Hargitai, Csilla,Nagy, Tamás,Halász, Judit,Koványi-Lax, Gy?rgyi,Németh, Gábor,Simig, Gyula,Volk, Balázs
, p. 7009 - 7017 (2018/10/24)
Two procedures for the synthesis of barely accessible 8-chloro-3,4-dihydroisoquinoline were investigated. The first approach is based on a directed ortho-lithiation of N-pivaloyl meta-chlorophenylethylamine, followed by formylation and subsequent ring closure under acidic conditions. In the second, more advantageous variant, the N-hydroxyethyl ortho-chlorobenzylamine intermediate undergoes a Friedel-Crafts reaction, and the resulting tetrahydro derivative is oxidized with N-bromosuccinimide. The 8-chloro-3,4-dihydroisoquinoline key intermediate is then applied in Suzuki reactions to give various 8-aryl-3,4-dihydroisoquinolines, which are finally treated with alkyl or aryllithiums to give 1-substituted 8-aryl-1,2,3,4-tetrahydroisoquinolines. These novel 1,2,3,4-tetrahydroisoquinoline derivatives can be used as building blocks in the synthesis of potential drug candidates.