61732-53-4

Basic information

• Product Name: 3-Cyclobutene-1,2-dione, 3,4-dipropoxy-
• CAS NO: 61732-53-4
• Molecular Formula: C10H14O4
• Mol File: 61732-53-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Cyclobutene-1,2-dione, 3,4-dipropoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Cyclobutene-1,2-dione, 3,4-dipropoxy-(61732-53-4)
• EPA Substance Registry System: 3-Cyclobutene-1,2-dione, 3,4-dipropoxy-(61732-53-4)

Safety Data

• Hazardous Substances Data: 61732-53-4(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 3200-96-2 2,3,4,4-tetrachloro-cyclobut-2-en-1-one 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 
• 2892-51-5 squaric acid 

Downstream Products

• 73279-63-7 4-Benzyl-3-propoxy-3-cyclobuten-1,2-dion 
• 43134-09-4 bis[4-(dimethylamino)phenyl]squaraine 

Relevant articles and documents

Synthesis of luminescent squaramide monoesters: Cytotoxicity and cell imaging studies in HeLa cells

Novel luminescent squaramide monoesters functionalised with different fluorophore groups have been synthesised and explored in cell imaging for the first time. Cytotoxicity studies performed in HeLa cervical cancer cells revealed high activity for some of these novel structures, highlighting the importance of the fluorescent fragment in the efficiency of these promising anticancer agents. In addition, fluorescence cell microscopy disclosed the different biodistribution behaviour depending on the fluorescent moiety, and the possibility of nuclear localisation of chiral non planar squaramide monoesters.

Preparation of 3-Alkoxy-4-alkyl-3-cyclobutene-1,2-diones

Several squaric acid esters (2a-g) are prepared.They react with Grignard compounds to give the title compounds (11a-n). 1,2- vs. 1,4-Grignard addition and the benzyl-tolyl rearrangement coincidental with the Grignard reaction are discussed.Hydrolysis of compounds 11 leads to 4-alkyl-3-hydroxy-3-cyclobutene-1,2-diones (12).