619-75-0

Basic information

• Product Name: alpha,alpha-dibromo-4-nitrotoluene
• Synonyms: alpha,alpha-dibromo-4-nitrotoluene;1-(Dibromomethyl)-4-nitrobenzene;1-Dibromomethyl-4-nitrobenzene;p-Nitrobenzal bromide;.alpha.,.alpha.-Dibromo-p-nitrotoluene;alpha,alpha-Dibromo-p-nitrotoluene;Benzene, 1-(dibromomethyl)-4-nitro-;MFCD00605327
• CAS NO: 619-75-0
• Molecular Formula: C₇H₅Br₂NO₂
• Molecular Weight: 294.9281
• EINECS: 210-612-1
• Mol File: 619-75-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 76-78 °C(Solv: ethanol (64-17-5))
• Boiling Point: 334.2°C at 760 mmHg
• Flash Point: 155.9°C
• Appearance: /
• Density: 2.038g/cm³
• Vapor Pressure: 0.000252mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: alpha,alpha-dibromo-4-nitrotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: alpha,alpha-dibromo-4-nitrotoluene(619-75-0)
• EPA Substance Registry System: alpha,alpha-dibromo-4-nitrotoluene(619-75-0)

Safety Data

• Hazardous Substances Data: 619-75-0(Hazardous Substances Data)

Usage

Description

alpha,alpha-dibromo-4-nitrotoluene, also known as 1-(dibromomethyl)-4-nitrobenzene, is an organic compound that serves as a valuable intermediate in the synthesis of various chemical products. It is characterized by its bromine and nitro functional groups, which contribute to its reactivity and potential applications in different industries.

Uses

Used in Chemical Synthesis:
alpha,alpha-dibromo-4-nitrotoluene is used as a key reactant for the synthesis of substituted benzaldehydes and 2-formylbenzonitriles. Its unique structure allows for the creation of a wide range of chemical products, making it an important building block in the chemical industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, alpha,alpha-dibromo-4-nitrotoluene can be utilized as an intermediate for the development of new drugs. Its reactivity and functional groups can be exploited to create novel compounds with potential therapeutic applications.
Used in Dye and Pigment Industry:
alpha,alpha-dibromo-4-nitrotoluene can also be used as an intermediate in the production of dyes and pigments, where its ability to form various substituted derivatives can be advantageous in creating a range of colors and properties.
Used in Agrochemical Industry:
alpha,alpha-dibromo-4-nitrotoluene may find applications in the agrochemical industry as a starting material for the synthesis of new pesticides or other agricultural chemicals, contributing to the development of more effective and environmentally friendly products.

InChI:InChI=1/C7H5Br2NO2/c8-7(9)5-1-3-6(4-2-5)10(11)12/h1-4,7H

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 14505-17-0 p-nitrobenzylidyne tribromide 
• 108-95-2 phenol 
• 555-16-8 4-nitrobenzaldehdye 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 127-09-3 sodium acetate 
• 75-25-2 Bromoform 
• 98-95-3 nitrobenzene 

Downstream Products

• 14505-17-0 p-nitrobenzylidyne tribromide 
• 555-16-8 4-nitrobenzaldehdye 
• 62-23-7 4-nitro-benzoic acid 
• 467-62-9 pararosaniline 
• 40795-04-8 3,5-dimethyl-2-(4-nitro-phenyl)-oxazolidine 
• 40795-08-2 1-[5-methyl-2-(4-nitro-phenyl)-oxazolidin-3-yl]-propan-2-ol 
• 2735-14-0 1,2-bis(4-nitrophenyl)acetylene 
• 67216-72-2 1-nitro-4-(ethoxymethyl)benzene 
• 78238-15-0 α,β-dibromo-4,4'-dinitrostilbene 
• 61081-34-3 methyl 4-nitrobenzylsulfone 
• 34063-53-1 p-nitrobenzyl phenyl sulfone 
• 455-14-1 4-trifluoromethylphenylamine 
• 402-45-9 4-hydroxybenzotrifluoride 
• 455-13-0 4-Iodobenzotrifluoride 

Relevant articles and documents

Production method of p-nitrobenzaldehyde

The invention discloses a production method of p-nitrobenzaldehyde. The method comprises: step 1, adding p-nitrotoluene to a reactor, and performing heating to make p-nitrotoluene become a molten material liquid; step 2, dropwise adding bromine into the p-nitrotoluene feed liquid until the reaction is complete; step 3, performing cooling to 40-60 DEG C, and adding an organic solvent into the reactor until the product is completely dissolved; step 4, adding a carbonate aqueous solution into the reactor, performing heating to a reflux state, performing hydrolyzing, and performing reacting for 15-20 hours; and step 5, performing stirring, cooling, crystallizing, filtering, washing and drying to obtain a finished product. The method has the advantages of having simplicity and high efficiency,improving the utilization rate of the raw materials, and increasing the yield of the product, and is suitable for preparing p-nitrobenzaldehyde.

Method for preparing benzyl bromide

The invention provides a method for preparing benzyl bromide. The method comprises the following steps: by taking bromine released from a redox reaction between bromates and negative bromide ions in the presence of an acid as a bromine source in an organic solvent, carrying out a benzyl radical substitution reaction with a methylbenzene compound shown as a formula I under initiation of an initiator, thereby obtaining a corresponding benzyl bromide compound shown a formula II, wherein in the formula II, m represents the number of Br and is equal to 1 or 2; when m is equal to 1, the formula II shows a benzyl monobromo compound; and when m is equal to 2, the formula II shows a benzyl dibromo compound. The reaction is carried out in an organic solvent, the initiator is combined and used, the radical substitution reaction is high in selectivity and wide in substrate application range, the substituent group replacing methylbenzene may be an electron-withdrawing group or an electron-donating group and can give extremely high yield on strong electron-donating groups (such as methoxy group). Moreover, the method disclosed by the invention is also applicable to preparation of benzyl dibromo compounds, and the product yield is high.

Rasta resin-triphenylphosphine oxides and their use as recyclable heterogeneous reagent precursors in halogenation reactions

Heterogeneous polymer-supported triphenylphosphine oxides based on the rasta resin architecture have been synthesized, and applied as reagent precursors in a wide range of halogenation reactions. The rasta resin-triphenylphosphine oxides were reacted with either oxalyl chloride or oxalyl bromide to form the corresponding halophosphonium salts, and these in turn were reacted with alcohols, aldehydes, aziridines and epoxides to form halogenated products in high yields after simple purification. The polymersupported triphenylphosphine oxides formed as a byproduct during these reactions could be recovered and reused numerous times with no appreciable decrease in reactivity.