61914-52-1

Basic information

• Product Name: 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-
• Synonyms: 1-(3,4-dimethoxyphenyl)-5-hydroxy-decan-3-one;O-Methyl-<6>-gingerol;3-Decanone,1-(3,4-dimethoxyphenyl)-5-hydroxy;<-Gingeryl-methylaether;Methylgingerol
• CAS NO: 61914-52-1
• Molecular Formula: C18H28O4
• Molecular Weight: 308.418
• Mol File: 61914-52-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 436.2±35.0 °C(Predicted)
• Density: 1.037±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-(61914-52-1)
• EPA Substance Registry System: 3-Decanone, 1-(3,4-dimethoxyphenyl)-5-hydroxy-(61914-52-1)

Safety Data

• Hazardous Substances Data: 61914-52-1(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 6302-60-9 4-(3,4-dimethoxy-phenyl)-butan-2-one 
• 66-25-1 hexanal 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 61871-73-6 methylzingerone trimethylsilyl ether 

Downstream Products

• 6302-60-9 4-(3,4-dimethoxy-phenyl)-butan-2-one 
• 79067-86-0 1-(3,4-dimethoxy-phenyl)-dec-4-en-3-one 
• 66-25-1 hexanal 
• 2380-78-1 homovanillyl alcohol 
• 7417-21-2 2-(3,4-dimethoxyphenyl)ethyl alcohol 

Relevant articles and documents

GINGEROL DERIVATIVE HAVING INHIBITORY ACTIVITY AGAINST BIOFILM FORMATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING BIOFILM-CAUSED INFECTION SYMPTOM

The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

Syntheses of the (+/-)--Gingerols (Pungent Principles of Ginger) and Related Compounds through Regioselective Aldol Condensations: Relative Pungency Assays

The deprotonation of trimethylsilylzingerone (13) by lithium di-isopropylamide at -78 deg C has been found to be regioselective (92 : 8 in favour of less-substituted enolate): the anion was condensed with alkanals and acyl imidazoles to give convenient syntheses of (+/-)--- and --gingerols (1) and -, -, and -gingerdiones (9).Similary, 3-methoxy-4-trimethylsilyloxybenzylideneacetone (17) gave the (+/-)---dehydrogingerols (8) and -, -, and -dehydrogingerdiones (10).The aldol reaction to -gingerol and methyl -gingerol was also conducted through a vinyloxyborane or through the enol silyl ether (TiCl4 catalysis).Results of organoleptic assays on these compounds are discussed, and the relation between pungency in the gingerols and in capsaicin is commented on.The aldol method was also used to synthesise the natural β-ketols(+/-)-daphneolone (25) and (+/-)-hexahydrocurcumin (4).