62040-85-1Relevant articles and documents
Synthesis of 9,10-anthraquinone monoalkylaminoalkylhydrazones as potential antitumor drugs
Antonini,Polucci,Cola,Palmieri,Martelli,Bontemps-Gracz
, p. 1641 - 1648 (2007/10/02)
In the constant search for new compounds endowed with antitumor activity we have synthesized a series of anthraquinone hydrazones, which can be seen either as opened-cycle modified anthrapyrazoles or as chromophore-modified anthracenediones. Seven 9,10-anthraquinone monoalkylaminoalkylhydrazones (3c-i) were synthesized from 10,10-dibromoanthrone (4) and a suitable N-alkylhydrazine. The hydrazones were converted into hydrochlorides and tested for their cytotoxic activity against L1210 murine leukemia cells. Two of them possess marginal activity in vitro.