62069-75-4

Basic information

• Product Name: DST
• Synonyms: DST;1,1'-[[(2R,3R)-2,3-Dihydroxy-1,4-dioxo-1,4-butanediyl]bis(oxy)]bis-2,5-pyrrolidinedione;DisucciniMidyl tartarate(DST);DST Crosslinker;Bis(2,5-dioxopyrrodilin-1-yl)(2R,3R)2,3dihydroxybutanedioate;Di(N-succinimidyl) L-Tartrate
• CAS NO: 62069-75-4
• Molecular Formula: C₁₂H₁₂N₂O₁₀
• Molecular Weight: 338.44
• Product Categories: Nitric Oxide Reagents;Cross Linking Reagents;Homobifunctional Crosslinker
• Mol File: 62069-75-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: Softens at 170°C, melts 195-197°C
• Boiling Point: 573.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.78±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• PKA: 10.61±0.20(Predicted)
• Stability: Moisture and Temperature Sensitive
• CAS DataBase Reference: DST(CAS DataBase Reference)
• NIST Chemistry Reference: DST(62069-75-4)
• EPA Substance Registry System: DST(62069-75-4)

Safety Data

• Hazardous Substances Data: 62069-75-4(Hazardous Substances Data)

Usage

Description

Disuccinimidyl tartarate is an amino reactive homobifunctional crosslinking reagent used for protein crosslinking. It features a spacer arm of 6.4 angstroms, which allows for efficient and specific crosslinking of proteins.

Uses

Used in Biochemistry Research:
Disuccinimidyl tartarate is used as a crosslinking agent for protein crosslinking in biochemistry research. Its amino reactive nature and 6.4 angstroms spacer arm enable the specific and efficient crosslinking of proteins, which is essential for studying protein-protein interactions and understanding the structure and function of proteins.
Used in Drug Development:
Disuccinimidyl tartarate is used as a protein crosslinking agent in drug development. By crosslinking proteins, it can help in the design and development of drugs that target specific protein-protein interactions, potentially leading to the discovery of new therapeutic agents.
Used in Diagnostics:
Disuccinimidyl tartarate is used as a protein crosslinking agent in the development of diagnostic tools. Its ability to crosslink proteins can be utilized in the creation of immunoassays and other diagnostic tests that rely on the detection of specific protein-protein interactions.
Used in Materials Science:
Disuccinimidyl tartarate is used as a crosslinking agent in the development of protein-based materials. Its ability to crosslink proteins can be employed to create materials with specific properties, such as improved stability or biocompatibility, for various applications in materials science.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 87-69-4 tartaric acid 

Relevant articles and documents

DLL3-TARGETING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF

The disclosure provides multispecific antigen-binding molecules that comprise a first antigen-binding moiety and a second antigen-binding moiety, each of which is capable of binding to CD3 and CD137, but does not bind to CD3 and CD137 at the same time; and a third antigen-binding moiety that is capable of binding to DLL3, preferably human DLL3, which induce T-cell dependent cytotoxity more efficiently whilst circumventing adverse toxicity concerns or side effects that other multispecific antigen-binding molecules may have. The present invention provides multispecific antigen-binding molecules and pharmaceutical compositions that can treat various cancers, especially those associated with DLL3, by comprising the antigen-binding molecule as an active ingredient.

Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents

Chitosan nanoparticles were obtained by crosslinking with two biocompatible dicarboxylic acids: polyethylene glycol dicarboxylic acid and tartaric acid. The water-in-oil (W/O) microemulsion method yielded particle sizes around 10-15 nm in the dried state (TEM) and 200-700 nm in the swollen state (QELS) from commercial chitosan. All the synthesized nanogels showed improved water solubility and most of them were stable at physiological pH. QELS studies revealed the influence of the hydrophilic character and flexibility of the crosslinker on the swelling behaviour of the nanogels. The nanoparticles showed a pH-sensitive volume transition that was consistent with the pKa of chitosan. The collected zeta potential data corroborated the electrostatic repulsion mechanism responsible for the pH-responsive behaviour.