621-33-0 Usage
Description
3-Ethoxyaniline is an organic compound that exists as a light yellow to dark red liquid. It is a derivative of aniline, with an ethoxy group attached to the third carbon atom. 3-Ethoxyaniline is known for its versatile chemical properties, making it a valuable intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
3-Ethoxyaniline is used as a starting reagent for the synthesis of 1,2,3,4-tetrahydroacridinylhydrazides, which are important compounds in the pharmaceutical industry. These hydrazides have potential applications as therapeutic agents, particularly in the development of drugs targeting various diseases and conditions.
Used in Chemical Synthesis:
Due to its unique chemical structure, 3-Ethoxyaniline serves as a valuable intermediate in the synthesis of a wide range of organic compounds. Its ability to participate in various chemical reactions, such as substitution, addition, and condensation, makes it a useful building block for creating complex molecules with diverse applications in different industries.
Used in Dye and Pigment Industry:
The light yellow to dark red color of 3-Ethoxyaniline makes it a potential candidate for use in the dye and pigment industry. Its color properties can be exploited to create a variety of dyes and pigments for use in textiles, plastics, and other materials.
Used in Research and Development:
3-Ethoxyaniline's versatile chemical properties also make it a valuable compound for research and development purposes. Scientists and researchers can use it to explore new reaction pathways, develop novel synthetic methods, and create new compounds with potential applications in various fields, such as medicine, agriculture, and materials science.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
3-Ethoxyaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard
3-Ethoxyaniline is probably combustible.
Safety Profile
Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 621-33-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 621-33:
(5*6)+(4*2)+(3*1)+(2*3)+(1*3)=50
50 % 10 = 0
So 621-33-0 is a valid CAS Registry Number.
621-33-0Relevant articles and documents
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Ph. Wagner
, p. 71 (1885)
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Synthesis method of m-phenetidine by one-pot reaction
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Paragraph 0033; 0034, (2016/12/07)
The invention discloses a synthesis method of m-phenetidine by a one-pot reaction. The method comprises the following steps: m-aminophenol, alkali and a solvent are thrown into a reaction vessel, and then only an alkylating agent or a catalyst and an alkylating agent are added at the same time, after materials are added, the reaction vessel is enclosed, and stirring is carried out for 0.5-1 hour at room temperature; the temperature is raised to 40-80 DEG C, a reaction is carried out for 1-8 hours, after the reaction, obtained reaction solution is cooled to room temperature and filtered, and filtrate is obtained; reduced pressure distillation for the filtrate is carried out, and m-phenetidine is obtained. The synthesis method of m-phenetidine has the characteristics of low reaction temperature, high safety performance, convenient operation, high purity and high yield of the product, etc.
[Cp?RhCl2]2-catalyzed alkyne hydroamination to 1,2-dihydroquinolines
Kumaran, Elumalai,Leong, Weng Kee
, p. 1779 - 1782 (2015/05/20)
[Cp?RhCl2]2 catalyzes the formation of 1,2-dihydroquinolines from the reaction of two terminal alkynes and an aniline. This reaction is believed to proceed via an alkyne hydroamination followed by an alkyne insertion.
