62133-07-7

Basic information

• Product Name: 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione;2-(4-NITRO-BENZYL)-ISOINDOLE-1,3-DIONE;2-[(4-nitrophenyl)methyl]isoindole-1,3-dione;N-(p-Nitrobenzyl)phthalimide
• CAS NO: 62133-07-7
• Molecular Formula: C₁₅H₁₀N₂O₄
• Molecular Weight: 282
• Mol File: 62133-07-7.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 484.3°C at 760 mmHg
• Flash Point: 246.7°C
• Appearance: /
• Density: 1.464g/cm³
• Vapor Pressure: 1.55E-09mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione(62133-07-7)
• EPA Substance Registry System: 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione(62133-07-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 62133-07-7(Hazardous Substances Data)

Usage

General Description

The chemical compound 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione is a nitrobenzyl-substituted isoindole-1,3(2H)-dione derivative. It is a yellow crystalline solid that is used in organic synthesis and chemical research. The compound is known for its potential applications in the pharmaceutical industry, particularly in the development of drugs for various therapeutic purposes. Its unique structure and reactivity make it a valuable building block for the synthesis of novel compounds with potential biological activity. Additionally, it has been studied for its potential use in the field of materials science, particularly in the development of functional materials and polymers. Overall, 2-(4-nitrobenzyl)-1H-isoindole-1,3(2H)-dione is a versatile and valuable chemical compound with promising applications in various scientific and industrial fields.

InChI:InChI=1/C15H10N2O4/c18-14-12-3-1-2-4-13(12)15(19)16(14)9-10-5-7-11(8-6-10)17(20)21/h1-8H,9H2

Upstream product

• 2142-01-0 N-benzylphthalimide 
• 100-14-1 4-nitrobenzyl chloride 
• 1074-82-4 potassium phtalimide 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 28627-68-1 phthalimide anion 
• 612-23-7 2-nitrobenzyl chloride 
• 85-44-9 phthalic anhydride 
• 7409-30-5 p-nitrobenzylamine 
• 136918-14-4 phthalimide 
• 7697-37-2 nitric acid 
• 39628-94-9 4-nitrobenzyl methanesulfonate 
• 619-73-8 4-nitrobenzyl chloride 
• 99-99-0 1-methyl-4-nitrobenzene 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 7409-30-5 p-nitrobenzylamine 
• 100880-61-3 2-(4-amino-benzyl)-isoindole-1,3-dione 
• 108621-05-2 N-(4-nitro-benzyl)-phthalamic acid 
• 20116-64-7 phthalazin-1,4-dione 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 94838-58-1 tert-butyl 4-nitrobenzylcarbamate 
• 94838-55-8 tert-butyl (4-aminobenzyl)carbamate 
• 502481-67-6 methyl (3S)-3-{2-[(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)amino]-2-oxoethyl}-7-chloro-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate 
• 502481-68-7 (3S)-3-{2-[(4-{[(tert-butoxycarbonyl)amino]methyl}phenyl)amino]-2-oxoethyl}-7-chloro-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylic acid 
• 56222-10-7 N-(4-nitrobenzyl)acetamide 
• 99362-10-4 N-(p-aminobenzyl)acetamide 
• 299402-87-2 3-[4-(acetamidomethyl)phenylthio]propionic acid 
• 4403-71-8 (4-aminomethyl)aniline 
• 100872-24-0 benzylidene-(4-nitro-benzyl)-amine 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Locking the Dynamic Axial Chirality of Biphenyl Crown Ethers through Threading

This paper describes the syntheses of [2]rotaxanes comprising 23- and 26-membered biphenyl crown ethers as the macrocyclic components and secondary ammonium ions as the dumbbell-shaped components, and the locking of the dynamic axial chirality of the biph

Targeting Her2-insYVMA with Covalent Inhibitors - A Focused Compound Screening and Structure-Based Design Approach

Mutated or amplified Her2 serves as a driver of non-small cell lung cancer or mediates resistance toward the inhibition of its family member epidermal growth factor receptor with small-molecule inhibitors. To date, small-molecule inhibitors targeting Her2 which can be used in clinical routine are lacking, and therefore, the development of novel inhibitors was undertaken. In this study, the well-established pyrrolopyrimidine scaffold was modified with structural motifs identified from a screening campaign with more than 1600 compounds, which were applied against wild-type Her2 and its mutant variant Her2-A775_G776insYVMA. The resulting inhibitors were designed to covalently target a reactive cysteine in the binding site of Her2 and were further optimized by means of structure-based drug design utilizing a set of obtained complex crystal structures. In addition, the analysis of binding kinetics and absorption, distribution, metabolism, and excretion parameters as well as mass spectrometry experiments and western blot analysis substantiated our approach.