62150-45-2

Basic information

• Product Name: 4-BROMO-PYRIDINE-2-CARBONITRILE
• Synonyms: AURORA 23233;4-BROMO-PYRIDINE-2-CARBONITRILE;4-BROMO-2-CYANOPYRIDINE;OTAVA-BB BB7110952495;4-Bromopicolinonitrile;4-Bromo-2-cyanopyridine, 4-Bromopicolinonitrile;4-BroMo-2-pyridinecarbonitrile;2-Cyano-4-bromopyridine
• CAS NO: 62150-45-2
• Molecular Formula: C₆H₃BrN₂
• Molecular Weight: 183.01
• EINECS: -0
• Product Categories: pharmacetical;Heterocyclic Compounds;Bases & Related Reagents;Heterocycles;Nucleotides;intermediate;6
• Mol File: 62150-45-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 82-84°C
• Boiling Point: 265.312 °C at 760 mmHg
• Flash Point: 114.257 °C
• Appearance: off-solid
• Density: 1.726 g/cm³
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: -2.73±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-PYRIDINE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-PYRIDINE-2-CARBONITRILE(62150-45-2)
• EPA Substance Registry System: 4-BROMO-PYRIDINE-2-CARBONITRILE(62150-45-2)

Safety Data

• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 62150-45-2(Hazardous Substances Data)

Usage

Description

4-BROMO-PYRIDINE-2-CARBONITRILE is an organic compound that serves as a valuable synthetic intermediate in the chemical industry. It is characterized by its off-solid chemical properties, which make it suitable for various applications in different fields.

Uses

Used in Pharmaceutical Industry:
4-BROMO-PYRIDINE-2-CARBONITRILE is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the synthesis of new drugs, contributing to the advancement of medical treatments.
Used in Chemical Synthesis:
In the chemical industry, 4-BROMO-PYRIDINE-2-CARBONITRILE is used as a synthetic intermediate for the production of various chemical compounds. Its off-solid properties make it an ideal candidate for use in the synthesis of a wide range of products, from specialty chemicals to advanced materials.
Used in Research and Development:
4-BROMO-PYRIDINE-2-CARBONITRILE is also utilized in research and development laboratories as a starting material for the exploration of new chemical reactions and the creation of novel compounds. Its unique properties make it a valuable tool for scientists and researchers working on the cutting edge of chemical innovation.

InChI:InChI=1/C8H8BrNO2/c1-2-12-8(11)7-5-6(9)3-4-10-7/h3-5H,2H2,1H3

Upstream product

• 14248-50-1 4-bromopyridine-1-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 1120-87-2 4-bromopyridin 
• 19524-06-2 4-bromopyridine hydrochloride 

Downstream Products

• 952742-96-0 4-(4-hydroxyphenyl)picolinonitrile 
• 802905-85-7 4-trimethylsilanylethynyl-pyridine-2-carbonitrile 
• 865156-50-9 1-(4-bromopyridin-2-yl)methanamine 
• 150971-76-9 N-t-butoxycarbonyl-3-(2-cyano-4-pyridyl)-(S)-alanine benzyl ester 
• 1035018-25-7 C₁₄H₁₁N₃O₂ 
• 1179360-58-7 4-bromopyridine-2-carboxamidine hydrochloride 
• 865156-53-2 7-methoxy-1,1,1-triphenyl-3-(4-bromopyridin-2-yl)-2-aza-1,λ5-phospha-heptane-1,3-diene 
• 1035018-24-6 [4-(2-aminomethyl-pyridin-4-yl)-phenyl]-carbamic acid methyl ester 
• 1357587-40-6 4-[3-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyridine-2-carboxamide 
• 1357588-21-6 N-{3-[4-(2-cyanopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide 
• 1357588-20-5 4-(4-(2-cyanopyridin-4-yl)-3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 1357588-18-1 N-{3-[4-(2-cyanopyridin-4-yl)-1-(tetrahydropyran-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide 
• 18714-16-4 4-phenyl-pyridine-2-carbonitrile 
• 1431616-38-4 4-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)picolinonitrile 

Relevant articles and documents

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure–activity relationship (SAR) studies of small molecule inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

Substituted 4-Hydroxypyrimidine-5-Carboxamides

The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.

Antituberculotics. XVII. Function derivatives of 4 halogenpicolinic acid and its N oxides (Czech)

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