622-44-6 Usage
Description
PHENYL ISOCYANIDE DICHLORIDE is a colorless to light yellow oily liquid with an onion-like odor. It is highly toxic by inhalation and skin absorption, and it strongly irritates skin and mucous membranes. The density of this compound is 1.265 g/cm3, and it is insoluble in water but soluble in alcohol. It is also noncombustible.
Uses
Used in Chemical Synthesis:
PHENYL ISOCYANIDE DICHLORIDE is used as a chemical intermediate for the synthesis of various organic compounds. Its reactivity and unique functional groups make it a valuable building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
PHENYL ISOCYANIDE DICHLORIDE is used as a key component in the development of new drugs due to its ability to react with various functional groups and form diverse molecular structures. It plays a crucial role in the synthesis of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
PHENYL ISOCYANIDE DICHLORIDE is used as a starting material for the production of agrochemicals, such as pesticides and herbicides. Its unique chemical properties allow for the creation of effective and targeted compounds that can help protect crops and enhance agricultural productivity.
Used in Research and Development:
PHENYL ISOCYANIDE DICHLORIDE is used as a research tool in academic and industrial laboratories to study the properties and reactivity of various chemical compounds. Its versatile nature makes it an essential component in the development of new materials and the advancement of scientific knowledge in the field of chemistry.
Synthesis Reference(s)
Journal of the American Chemical Society, 44, p. 2896, 1922 DOI: 10.1021/ja01433a027
Air & Water Reactions
Insoluble in water. Slowly decomposed in water.
Reactivity Profile
PHENYL ISOCYANIDE DICHLORIDE may be incompatible with water, strong oxidizing agents, alcohols. Sealed containers held at room temperature may explode, due to slow decomposition that builds up pressure. This situation is more dangerous with heat. May react vigorously or explosively with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.
Safety Profile
A poison by inhalation. When heated to decomposition it emits toxic vapors of NOx and Cl
Potential Exposure
Phenylcarbylamine is used in organic synthesis; making other chemicals. A laboratory chemical and a former battlefield gas
Shipping
UN1672 Phenylcarbylamine chloride, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard; Inhalation Hazard Zone B. PGI.
Incompatibilities
Reacts slowly with water releasing hydrogen chloride. Sealed containers stored at room temperature may explode, due to slow decomposition that builds up pressure. Heat increases the danger of explosion . Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. alcohols.
Waste Disposal
Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. It is not appropriate to dispose of expired or waste product such as lab chemicals by flushing them down the toilet or discarding them to the trash. Larger quantities shall carefully take into consideration applicable EPA, and FDA regulations. If possible return the lab chemicals to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste lab chemicals shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. All federal, state, and local environmental regulations must be observed.
Check Digit Verification of cas no
The CAS Registry Mumber 622-44-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 622-44:
(5*6)+(4*2)+(3*2)+(2*4)+(1*4)=56
56 % 10 = 6
So 622-44-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H5Cl2N/c8-7(9)10-6-4-2-1-3-5-6/h1-5H
622-44-6Relevant articles and documents
Synthesis and antimicrobial activity of 3-aryl-2,6-diphenylimino-4-S-hcpta- O-benzoyl-lactosyl-2,3-dihydro-1,3,5-thiadiazine hydrochlorides
Deshmukh, Reena J.,Deshmukh, Shirish P.
, p. 1027 - 1031 (2013/09/23)
A new series 3-aryl-2,6-diphenylimino-4-S-hepta-O-benzoyl-lactosyl-2,3- dihydro-1,3,5-thiadiazine hydrochlorides have been synthesized by the interaction of S-hepta-O-benzoyl-lactosyl-1,5-disubstituted-2,4-isodithiobiurets and phenyl isocyanodichloride. The newly synthesized compounds have been characterised by analytical and IR, 1H NMR and Mass spectral studies. These newly synthesized thiolactosides are also tested for antibacterial and antifungal activity.
Lifetimes of imidinium ions in aqueous solution
Dalby, Kevin N.,Jencks, William P.
, p. 7271 - 7280 (2007/10/03)
Imidinium ions, ArN=CNR2+, were generated in aqueous solution from the solvolysis of fluoro and chloro formamidines at pH 9.3 and 25°C. Rate constants for the hydration of five imidinium ions were determined from a kinetic analysis of their trapping by thiolacetate anion, CH3COS-, in the presence of a pool of competing fluoride anion, and a rate constant of k(AcS)- = 5 x 109 M-1 S-1 for diffusion-controlled trapping of the carbocations with thiolacetate anion. The rate constants, k(s), for hydration of the imidinium ions, XArN=CNC4H8O+ are 3.6 x 105, 5.8 x 105, 1.5 x 106, 1.6 x 106, and 1.8 x 106 s-1 for X = H, 4-Cl, 3-CN, 4-CN, and 3-NO2, respectively. In a similar experiment a rate constant of k(s) = 3.3 x 107 s-1 was obtained for hydration of the imidinium ion 4-NO2-ArN=CNCH3(OCH3)+, by using azide anion to trap the cation and a rate constant of k(az) = 5 x 109 M-1 s-1 for diffusion-controlled trapping of the imidinium ion with azide ion. The partitioning rate constant ratio k(AcS)-/k(s) for 4-ClArN=CNC4H8O+ decreases by approximately 6-fold in 45% v/v glycerol/water in contrast to k(az)/k(s), which remains almost constant, showing that thiolacetate, but not azide anion, combines with the imidinium ion at a diffusion-limited rate. The reactivity of the imidinium ions deviate from behavior predicted by the N+ scale in a manner that may be explained by a difference in the selectivity of the cation when compared to the more stable N+ carbocations.
Photochemical Reactions of Primary Aromatic Amines with Chloromethanes in Solution. II. The Products and Mechanisms of Partial Reactions of Aniline in Tetrachloromethane, Chloroform and Dichloromethane
Boszczyk, Wojciech,Latowski, Tadeusz
, p. 1589 - 1592 (2007/10/02)
Major products of photochemical reactions of aniline in tetrachloromethane, chloroform and dichloromethane have been isolated and identified.The mechanisms of partial reactions have been discussed. - Keywords: Photochemical Reactions, Primary Aromatic Amines, Chloromethanes
