62210-73-5Relevant articles and documents
Preparation method of plazomicin
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Paragraph 0032-0034, (2020/03/29)
The invention discloses a preparation method of plazomicin. According to the invention, 6'amino of sisomicin and Cbz-ONB make a nucleophilic substitution reaction under the action of selective coordination and chelation of zinc acetate to obtain a compound 2; all hydroxyl groups and other amino groups of the compound 2 are protected by using silanization reagent to generate a full silanization product; the full silanization product and N-t-butyloxycarboryl-4-amino-2(S)-hydroxybutyric acid make selective condensation and a silane protection group is removed to obtain a compound 4; other amino groups in the compound 4 are protected by a Boc protecting group to obtain a compound 5; and then reaction is performed on the compound 5 to obtain plazomicin. Compared with an original research route,the disclosed process has advantages of being short in synthesis steps, mild in experimental conditions, simple, easy to operate and thus is suitable for industrial production.
RNA targeting compounds and methods for making and using same
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Page/Page column 53; 54, (2016/03/13)
Disclosed are RNA targeting compounds, methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed.
Chemical modification of sorbistin. I. N acyl analogs of sorbistin
Naito,Nakagawa,Narita,Kawaguchi
, p. 1286 - 1296 (2007/10/11)
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