6223-35-4 Usage
Description
Sodium gualenate, an active ingredient derived from chamomile flowers, is known for its potent anti-pepsin, anti-inflammatory, antibacterial, anti-allergic properties, and its ability to promote mucosal metabolism. Sodium gualenate is unstable and prone to decomposition under light, air oxidation, and high-temperature conditions. It is also susceptible to the removal of the sulfonic acid group, with sodium azulene sulfonate commonly containing half or one crystal water.
Uses
Used in Pharmaceutical Industry:
Sodium gualenate is used as a therapeutic agent for treating gastrointestinal conditions such as duodenal ulcer, gastric ulcer, and gastritis. Its multifaceted properties, including anti-inflammatory and antibacterial actions, make it a valuable component in the development of medications aimed at alleviating these ailments and promoting healing.
Used in Research and Development:
Due to its various biological activities, sodium gualenate is also utilized in research and development for exploring its potential in other medical applications. Its anti-allergic and promotion of mucosal metabolism properties may lead to further discoveries in treating allergies and enhancing the body's natural defenses.
Mechanism of action
Sodium gualenate inhibits the release of histamine from inflammatory cells through local direct action; increases the synthesis of prostaglandin E2 in the mucosa, promotes granulation formation and epithelial cell regeneration; and can reduce the activity of pepsin.
Check Digit Verification of cas no
The CAS Registry Mumber 6223-35-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,2 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6223-35:
(6*6)+(5*2)+(4*2)+(3*3)+(2*3)+(1*5)=74
74 % 10 = 4
So 6223-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H18O3S.Na/c1-9(2)12-6-5-10(3)15-13(8-12)11(4)7-14(15)19(16,17)18;/h5-9H,1-4H3,(H,16,17,18);/q;+1/p-1
6223-35-4Relevant articles and documents
Synthesis and Biological Evaluation of 3, 8-dimethyl-5-isopropylazulene Derivatives as Anti-gastric Ulcer Agent
Cao, Tingting,Li, Yong,Yang, Ziyao,Yuan, Mingxing,Li, Ying,Yang, Hongjun,Feng, Yuchuan,Yin, Shufan
, p. 264 - 271 (2016)
Recent studies showed that Guaiazulene (GA) and Sodium guaiazulene sulfonate (GAS-Na) have good anti-gastric ulcer effect. Here, two series of GA derivatives were synthesized and evaluated for their anti-gastric ulcer activity. The data obtained from in vivo testing of these compounds in a rodent ethanol-induced stomach injury model are discussed. Among the tested compounds, A1, A4, and A9 (ulcer index: 1.125 ± 1.246**, 1.714 ± 0.756*, 1.875 ± 1.126*) exhibited better anti-gastric ulcer activity than the positive control Omeprazole (2.005 ± 1.011*). The information got from these studies and the results of 3D-SAR investigation may be useful in the design of novel anti-gastric ulcer agents.
N-SUBSTITUTED ISOPROPYLDIMETHYL AZULENE SULFONAMIDE DERIVATIVES, AND PREPARATION METHOD AND USE THEREOF
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Paragraph 0108-0110, (2014/08/06)
The present invention provides an N-substituted isopropyldimethyl azulene sulfonamide derivative as represented by formula (I), and preparation method and uses thereof, wherein R1 is an alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, amino, or a substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, and amino. The N-substituted isopropyldimethyl azulene sulfonamide derivative can be used in treating gastric ulcer.