622369-40-8 Usage
General Description
4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE is an organic chemical compound with the molecular formula C11H7ClFNO2. It is a quinoline derivative that contains a carbonitrile group. This chemical is commonly used in pharmaceutical research and drug development, particularly in the synthesis of compounds with potential biological activity. Its unique structure and properties make it a valuable intermediate for the production of various pharmaceuticals and agrochemicals. Additionally, its presence of chlorine, fluorine, and methoxy groups contribute to its potential pharmacological properties and make it an important target for further studies and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 622369-40-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,2,3,6 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 622369-40:
(8*6)+(7*2)+(6*2)+(5*3)+(4*6)+(3*9)+(2*4)+(1*0)=148
148 % 10 = 8
So 622369-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H6ClFN2O/c1-16-10-2-7-9(3-8(10)13)15-5-6(4-14)11(7)12/h2-3,5H,1H3
622369-40-8Relevant articles and documents
3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors
-
Page/Page column 13, (2009/10/30)
Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.
7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases
Boschelli, Diane H.,Wang, Yanong D.,Johnson, Steve,Wu, Biqi,Ye, Fei,Barrios Sosa, Ana Carolina,Golas, Jennifer M.,Boschelli, Frank
, p. 1599 - 1601 (2007/10/03)
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina