62248-45-7

Basic information

• Product Name: Benzene, 1-(1,1-dimethylethyl)-4-[(4-nitrophenyl)thio]-
• CAS NO: 62248-45-7
• Molecular Formula: C16H17NO2S
• Molecular Weight: 287.382
• Mol File: 62248-45-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1,1-dimethylethyl)-4-[(4-nitrophenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1,1-dimethylethyl)-4-[(4-nitrophenyl)thio]-(62248-45-7)
• EPA Substance Registry System: Benzene, 1-(1,1-dimethylethyl)-4-[(4-nitrophenyl)thio]-(62248-45-7)

Safety Data

• Hazardous Substances Data: 62248-45-7(Hazardous Substances Data)

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 2396-68-1 4-t-butylbenzenethiol 
• 586-78-7 para-nitrophenyl bromide 
• 54166-35-7 NaSph-4-Cme₃ 
• 100-00-5 4-chlorobenzonitrile 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 100-25-4 para-dinitrobenzene 
• 636-99-7 4-nitrophenylhydrazine hydrochloride 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 54457-72-6 4'-t-Butyl-4-aminodiphenylsulfid 

Relevant articles and documents

Metal-Free Cercosporin-Photocatalyzed C-S Coupling for the Selective Synthesis of Aryl Sulfides under Mild Conditions

Aryl sulfides are important motifs of bioactive molecules, which are generally synthesized by transition metal-based coupling reactions under harsh conditions. Herein, we developed a new method that visible light along with cercosporin, produced by liquid fermentation and functioned as a cost-effective and environmentally friendly photocatalyst, prompted the selective synthesis of aryl sulfides through C–S coupling of thiols and diazonium salts under mild conditions. Furthermore, this method can also be performed with a great conversion by the direct use of cercosporin-containing fermentation supernatant as catalytic system without organic solvent extraction.

C-S coupling with nitro group as leaving group via simple inorganic salt catalysis

An efficient and practical synthetic protocol to synthesize nonsymmetrical aryl thioethers by nucleophilic aromatic substitution (SNAr) reaction of nitroarenes by thiols with potassium phosphate as the catalyst is described. Various moderate to strong electron-withdrawing functional groups are tolerated by the system to provide thioethers in a good to excellent yields. We also showed that the present method allows access to 3 drug examples in a short reaction time. Finally, mechanistic studies suggest that the reaction may form the classic Meisenheimer complex through a two-step addition-elimination mechanism.

KF/clinoptilolite: An efficient promoter for the synthesis of thioethers

Potassium fluoride impregnated on natural zeolite as a new solid base system effectively catalyzes the coupling of thiophenols with electron-deficient fluoro-, chloro- and bromo-arenes in DMSO. This versatile and efficient solid base has been demonstrated to afford the corresponding desired products in good to excellent yields. This procedure provides a convenient, efficient and practical method for the preparation of diaryl thioethers.