62268-16-0Relevant articles and documents
Synthetic method
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, (2008/06/13)
A process for the preparation of the compound AQ4 of formula 3: or a salt or N-oxide thereof, includes the step:
Process improvements in the synthesis of 2,4,5-trifluorobenzoic acid. selective hydrodefluorination of tetrafluorophthalimides
Fertel, Lawrence B.
, p. 111 - 115 (2013/09/08)
An improved preparation of the fluoroquinolone antibacterial intermediate 2,4,5-trifluorobenzoic acid is described. A combination of a selective hydrodefluorination and hydrolysis reaction of 3,4,5,6-tetrafluoro-N-methylphthalimide leading to 3,5,6-trifluorophthalic acid was key to the success of the process. In addition the development of a two-step, one-pot imidization/ halogen exchange from tetrachlorophthalic anhydride to 3,4,5,6-tetrafluoro-N-methylphthalimide in sulfolane solvent is detailed.
Optimization of Reaction Variables in the Selective Hydrodechlorination of Chlorinated Phthalic Anhydrides and Acids: Preparation of 3,6-Dichlorophthalic Acid and 3-Chlorophthalic Acid
Fertel, Lawrence B.,O'Reilly, Neil J.,Callaghan, Kathleen M.
, p. 261 - 263 (2007/10/02)
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