6245-04-1

Basic information

• Product Name: 2-HYDROXY-3-METHYL-BENZOIC ACID
• Synonyms: Einecs 228-356-4
• CAS NO: 6245-04-1
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• EINECS: 228-356-4
• Mol File: 6245-04-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 303.5 °C at 760 mmHg
• Flash Point: 151.6 °C
• Appearance: /
• Density: 1.249 g/cm³
• Vapor Pressure: 0.000408mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2-HYDROXY-3-METHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3-METHYL-BENZOIC ACID(6245-04-1)
• EPA Substance Registry System: 2-HYDROXY-3-METHYL-BENZOIC ACID(6245-04-1)

Safety Data

• Hazardous Substances Data: 6245-04-1(Hazardous Substances Data)

Usage

Description

2-Hydroxy-3-methyl-benzoic acid, also known as methyl gallic acid, is a naturally occurring organic compound belonging to the class of hydroxybenzoic acids. It is characterized by the presence of a hydroxyl group at the 2nd position and a methyl group at the 3rd position on a benzene ring, with a carboxylic acid group attached. This molecule exhibits weak acidic properties and is known for its potential applications in various fields due to its chemical structure and functional groups.

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-3-methyl-benzoic acid is used as a reagent for the mild synthesis of substituted salicylic acids and other heterocycles. These synthesized compounds have potential applications in the development of pharmaceuticals, particularly for the treatment of various diseases and conditions. The mild synthesis process allows for the production of these compounds with minimal side reactions and improved yields.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Hydroxy-3-methyl-benzoic acid serves as a versatile building block for the creation of various organic compounds. Its unique structure allows for the formation of different functional groups and molecular architectures, making it a valuable precursor in the synthesis of complex organic molecules.
Used in Research and Development:
2-Hydroxy-3-methyl-benzoic acid is also utilized in research and development settings to study the properties and behavior of hydroxybenzoic acids and their derivatives. This knowledge can contribute to the advancement of scientific understanding and the development of new applications for these compounds.

InChI:InChI=1/C9H10O3/c1-5-3-6(2)8(10)7(4-5)9(11)12/h3-4,10H,1-2H3,(H,11,12)

Upstream product

• 14438-32-5 3,5-dimethylanthranilic acid 
• 1198-66-9 3,5-dimethyl-2-hydroxyacetophenone 
• 527-60-6 Mesitol 
• 35471-28-4 sodium 2,4-dimethylphenolate 
• 15719-64-9 methylammonium carbonate 
• 137-40-6 sodium proprionate 
• 123-62-6 propionic acid anhydride 
• 95646-18-7 3-(2-Hydroxy-3,5-dimethyl-benzoyl)-2-p-tolyl-2,3-dihydro-isoindol-1-one 
• 21553-47-9 2-Methoxy-3,5-dimethylbenzoic acid 
• 7732-18-5 water 
• 7664-93-9 sulfuric acid 
• 124-38-9 carbon dioxide 
• 105-67-9 2,4-Xylenol 
• 62508-70-7 3,5-dimethyl-2-sulfo-benzoic acid 

Downstream Products

• 117369-92-3 methyl 2-hydroxy-3,5-dimethylbenzoate 
• 40617-52-5 2,6-dicarboxylic acid-4-methylphenol 
• 121031-61-6 2-hydroxy-3,5-dimethyl-benzoyl chloride 
• 105-67-9 2,4-Xylenol 
• 90481-47-3 2-(2′-hydroxy-3′,5′-dimethylphenyl)benzothiazole 
• 4397-13-1 2-hydroxymethyl-4,6-dimethylphenol 
• 124-38-9 carbon dioxide 
• 129117-85-7 dimethyl 2-hydroxy-5-methylbenzene-1,3-dicarboxylate 
• 57536-11-5 2-hydroxy-3,5-dimethyl-benzoic acid amide 

Relevant articles and documents

Aryl phenol compound as well as synthesis method and application thereof

The invention discloses a synthesis method of an aryl phenol compound shown as a formula (3). All systems are carried out in an air or nitrogen atmosphere, and visible light is utilized to excite a photosensitizer for catalyzation. In a reaction solvent, ArNR1R2 as shown in a formula (1) and water as shown in a formula (2) are used as reaction raw materials and react under the auxiliary action of acid to obtain the aryl phenol compound as shown in a formula (3). The ArNR1R2 in the formula (1) can be primary amine and tertiary amine, can also be steroid and amino acid derivatives, and can also be drugs or derivatives of propofol, paracetamol, ibuprofen, oxaprozin, indomethacin and the like. The synthesis method has the advantages of cheap and easily available raw materials, simple reaction operation, mild reaction conditions, high reaction yield and good compatibility of substrate functional groups. The fluid reaction not only can realize amplification of basic chemicals, but also can realize amplification of fine chemicals, such as synthesis of drugs propofol and paracetamol. The invention has wide application prospect and use value.

Process for preparing hydroxybenzoic acids

A process for preparing a hydroxybenzoic acid is herein disclosed which comprises reacting a phenol with an alkali metal compound by the use of an aprotic polar organic solvent as a reaction solvent to form an alkali metal salt of the phenol, and then reacting this alkali metal salt with carbon dioxide to obtain a hydroxybenzoic acid, said process comprising the step of carrying out the reaction under conditions that a molar ratio of the phenol to the total of the alkali metal compound and the aprotic polar organic solvent is larger than 1. Furthermore, the process may contain the steps of precipitating crystals from the reaction solution, separating the solid from the solution to obtain a wet alkali metal salt of the hydroxybenzoic acid, dissolving the wet alkali metal salt in water, and precipitating crystals from the solution by acidification to obtain the hydroxybenzoic acid.