62498-69-5 Usage
Description
DIDESMETHYL CITALOPRAM-D4, a metabolite of Citalopram, is an inhibitor of serotonin (5-HT) uptake. It is characterized by its pale yellow thick oil appearance and plays a significant role in the treatment of depression.
Uses
Used in Pharmaceutical Industry:
DIDESMETHYL CITALOPRAM-D4 is used as an antidepressant for the treatment of depression. As a metabolite of Citalopram, it contributes to the overall efficacy of the drug in modulating serotonin levels in the brain, thereby alleviating depressive symptoms and improving the patient's mood and overall well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 62498-69-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,4,9 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 62498-69:
(7*6)+(6*2)+(5*4)+(4*9)+(3*8)+(2*6)+(1*9)=155
155 % 10 = 5
So 62498-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H17FN2O/c19-16-5-3-15(4-6-16)18(8-1-9-20)17-7-2-13(11-21)10-14(17)12-22-18/h2-7,10H,1,8-9,12,20H2
62498-69-5Relevant articles and documents
Improved syntheses of N-desmethylcitalopram and N,N-didesmethylcitalopram
Jin, Chunyang,Boldt, Karl G.,Rehder, Kenneth S.,Brine, George A.
, p. 901 - 908 (2007/10/03)
An improved and efficient synthesis of N-desmethylcitalopram (2) and N,N-didesmethylcitalopram (3) is presented. The method involved N-demethylation of citalopram (1) using 1-chloroethyl chloroformate to give 2 in 87% yield. Synthesis of 3 was accomplished by alkylation of 8 with 1-(3-bromopropyl)-2,2,5, 5-tetramethyl-1-aza-2,5-disilacyclopentane (9). Copyright Taylor & Francis Group, LLC.
PREPARATION OF ESCITALOPRAM
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Page/Page column 26-27, (2008/06/13)
Enantiomerically enriched citalopram is prepared by methylating enantiomerically enriched didesmethylcitalopram, obtained by directly resolving racemic didesmethylcitalopram using a chiral acid.