625-24-1

Basic information

• Product Name: 2,2,2-TRICHLOROETHYL ACETATE
• Synonyms: 2,2,2-TRICHLOROETHYL ACETATE;2,2,2-trichloroethyl ethanoate
• CAS NO: 625-24-1
• Molecular Formula: C₄H₅Cl₃O₂
• Molecular Weight: 191.44
• Product Categories: C2 to C5Alphabetic;Carbonyl Compounds;Esters;TP - TZ
• Mol File: 625-24-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 238.3°C at 760 mmHg
• Flash Point: 105.7°C
• Appearance: /
• Density: 1.401 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0427mmHg at 25°C
• Refractive Index: n20/D 1.457
• BRN: 1757888
• CAS DataBase Reference: 2,2,2-TRICHLOROETHYL ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRICHLOROETHYL ACETATE(625-24-1)
• EPA Substance Registry System: 2,2,2-TRICHLOROETHYL ACETATE(625-24-1)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45
• WGK Germany: 3
• RTECS: AJ8300000
• F: 10-21
• Hazardous Substances Data: 625-24-1(Hazardous Substances Data)

Usage

Description

2,2,2-Trichloroethyl acetate is an organic compound with the chemical formula C4H6Cl3O2. It is a colorless liquid with a chloroform-like odor and is soluble in organic solvents. 2,2,2-TRICHLOROETHYL ACETATE is known for its reactivity and is commonly used as an intermediate in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
2,2,2-Trichloroethyl acetate is used as a reagent in the enzyme-catalyzed synthesis of enantiomerically pure prostaglandin intermediate, (1S,4R)-(-)-4-hydroxy-2-cyclopentenyl acetate. Prostaglandins are a group of bioactive compounds that play a crucial role in various physiological processes, including inflammation, blood clotting, and smooth muscle contraction. The enantiomerically pure intermediate is essential for the development of pharmaceuticals with improved efficacy and reduced side effects.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 3020, 1953 DOI: 10.1021/ja01108a506

InChI:InChI=1/C4H5Cl3O2/c1-3(8)9-2-4(5,6)7/h2H2,1H3

Upstream product

• 82564-87-2 diethyl β,β,β-trichloroethyl phosphite 
• 64-19-7 acetic acid 
• 87938-01-0 2,2,5-Trimethyl-5-(2,2,2-trichloro-ethoxy)-2,5-dihydro-[1,3,4]oxadiazole 

Downstream Products

• 54664-61-8 cis-1,4-diacetoxy-2-cyclopentene 
• 60176-77-4 (1S,4R)-4-hydroxy-2-cyclopentenyl acetate 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 75-35-4 1,1-Dichloroethylene 

Relevant articles and documents

Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides

The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

REACTIONS OF DIETHYL 2,2,2-TRICHLOROETHYL PHOSPHITE WITH CARBOXYLIC ACIDS

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