62567-91-3Relevant articles and documents
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides
Tichy, Michal,Pohl, Radek,Hocek, Michal,Xu, Hao Ying,Chen, Yen-Liang,Yokokawa, Fumiaki,Shi, Pei-Yong
, p. 6123 - 6133,11 (2012)
A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4, 5-b]indole ribonucleoside with (het)arylboronic acids or stannanes followed by deprotection. Further cross-couplings under harsher conditions and employing X-Phos ligand proceeded at the position 6 leading to 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides. Some of these compounds displayed antiviral activity against Dengue virus.