6258-28-2Relevant articles and documents
PHARMACEUTICAL COMPOSITIONS
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Page/Page column 5-6, (2011/04/25)
The object of the present invention is to provide a pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-κB. The pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-κB contains DTCM glutarimide of the Formula (I) as an effective ingredient, thereby being able to inhibit nitric oxide (NO)production and prostaglandin production.
Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB
Ishikawa, Yuichi,Tachibana, Miyuki,Matsui, Chino,Obata, Rika,Umezawa, Kazuo,Nishiyama, Shigeru
scheme or table, p. 1726 - 1728 (2009/11/30)
Synthesis of 9-methylstreptimidone analogs and their inhibitory activities against NF-κB (nuclear factor-κB) are reported. Among several active derivatives synthesized in this study, 8 with a relatively simple structure, exhibited inhibitory activity agai