626-00-6

Basic information

• Product Name: 1,3-DIIODOBENZENE
• Synonyms: 1,3-diiodo-benzen;Benzene, 1,3-diiodo-;Benzene, m-diiodo-;benzene,1,3-diiodo-;Benzene,m-diiodo-;M-DIIODOBENZENE;1,3-DIIODOBENZENE;1,3-Diiodobenzene,98+%
• CAS NO: 626-00-6
• Molecular Formula: C₆H₄I₂
• Molecular Weight: 329.9
• EINECS: 210-921-1
• Product Categories: Organics;Iodine Compounds;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 626-00-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 34-37 °C(lit.)
• Boiling Point: 285°C
• Flash Point: >230 °F
• Appearance: Yellow to beige/Low Melting Crystalline Mass, Powder or Crystals
• Density: 2.47
• Vapor Pressure: 0.00474mmHg at 25°C
• Refractive Index: 1.7179 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Methanol (Slightly, Heated)
• Water Solubility: Insoluble in water. Soluble in hot methanol.
• Sensitive: Light Sensitive
• BRN: 1904540
• CAS DataBase Reference: 1,3-DIIODOBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIIODOBENZENE(626-00-6)
• EPA Substance Registry System: 1,3-DIIODOBENZENE(626-00-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 626-00-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 626-00-6 differently. You can refer to the following data:
1. suzuki reaction
2. 1,3-Diiodobenzene may be used in the synthesis of:3,5-bis(perfluorodecyl)phenylboronic acidepitaxially aligned and separated polyphenylene lines on Cu(110)1,3-bis(4-ethynyl-2,5-dibutoxyphenyl-1-ethynyl)benzene

General Description

1,3-Diiodobenzene is a halogenated benzene derivative. Its reaction with phenylboronic acid in the presence of CuI, DABCO (1,4-diazabicyclo[2.2.2]octane) and TBAB (n-Bu4NBr) has been analyzed. 1,3-Diiodobenzene undergoes coupling with 2-methylthiophene in the presence of Ir/Ag2CO3 to afford meta-linked isomer of thiophene-benzene-thiophene triad.

InChI:InChI=1/C6H4I2/c7-5-2-1-3-6(8)4-5/h1-4H

Upstream product

• 533-70-0 2,4-diiodoaniline 
• 15658-61-4 1,3-dihydrazino-benzene 
• 2060-89-1 m-bis(trimethylsilyl)benzene 
• 591-50-4 iodobenzene 
• 108-95-2 phenol 
• 16156-47-1 Isophthaloyljodid 
• 19260-01-6 C₈H₇IN₂O₂ 
• 25723-55-1 phenylene-1,3-diammonium sulfate 
• 7732-18-5 water 
• 7553-56-2 iodine 
• 109-99-9 tetrahydrofuran 
• 109-72-8 n-butyllithium 
• 153688-92-7 3-iodophenyl trifluoromethanesulfonate 
• 626-39-1 1,3,5-trisbromobenzene 

Downstream Products

• 6304-47-8 1-diacetoxyiodanyl-3-iodo-benzene 
• 221037-98-5 (3-iodophenyl)boronic acid 
• 1486-01-7 biphenyl-d10 
• 78486-58-5 1,3-di(phenyl-d5)benzene 
• 92-52-4 biphenyl 
• 135-70-6 p-quaterphenyl 
• 13476-68-1 1,1':4',1'':3'',1''':4''',1''''-quinquephenyl 
• 641-96-3 2,2'-diphenylbiphenyl 
• 5660-37-7 2',2''-diphenyl-m-terphenyl 
• 1166-18-3 meta-quaterphenyl 
• 16716-13-5 m-quinquephenyl 
• 78626-57-0 3-iodo-m-terphenyl 
• 130247-04-0 1-<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>-3-iodobenzene 
• 130247-12-0 1,3-bis<2-(benzyloxycarbonyl)-2-<(tert-butoxycarbonyl)amino>ethenyl>benzene 

Relevant articles and documents

NEW COMPOUND

PROBLEM TO BE SOLVED: To provide a new compound that does not have structural similarity to ceramide and has excellent CERT inhibitory activity. SOLUTION: The present invention provides a new compound of structural formula (I). A bond group -X- is cis-cyclopropyl-, R1, R2, R3, R4, and R5 independently represent a hydrogen atom, a halogen atom, a linear or branched C1-C8 alkyl group that may have a halogen atom, or OR6. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT

A simple and efficient two-step synthesis of 1,2,3-triiodoarenes via consecutive C-H iodination/ipso-Iododecarboxylation strategy: A potential application towards Ortho-diiodoarenes by Regioselective metal-iodine exchange reaction

A general, robust, and efficient method for the conversion of benzoic acids to 1,2,3-triiodoarenes and 1,2,3-trihaloarenes via a two-step synthesis is reported. Commercially available benzoic acids were used that can allow the reactions to be performed on multi-gram scales with good-to-excellent yields. This report discloses a practical method for the synthesis of 1,2,3-triiodoarenes and 1,2,3-trihaloarenes that is general in scope, scalable, and easy to workup and purify. A potential application of the target compounds as precursors for novel regioselective metal-iodine exchange reaction of 1,2,3-triiodoarenes was also demonstrated. It provided ortho-diiodoaryl derivatives in a high regioselective fashion that are useful intermediates in synthesis and indeed are hard to synthesize by any other means.

Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2

3-Aryltyramines were prepared in one single step from tyramine and various arenediazonium salts by radical arylation. Binding as well as enzyme inhibition data of the 14 compounds do not prove true interaction with BACE-1. In contrast, with BACE-2 inhibition and binding could be confirmed indicating that 3-aryltyramines are potential starting points for a drug discovery effort.