626-03-9 Usage
Description
2,4-Dihydroxypyridine, also known as 3-deazauracil, is an organic compound with the molecular formula C5H4N2O2. It is a heterocyclic compound that features a pyridine ring with two hydroxyl groups attached at the 2nd and 4th positions. 2,4-Dihydroxypyridine is known for its potential applications in various chemical and pharmaceutical processes due to its unique structure and reactivity.
Uses
Used in Pharmaceutical and Chemical Synthesis:
2,4-Dihydroxypyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds and organic molecules. Its presence in the molecule allows for the formation of new chemical bonds and the creation of diverse chemical entities.
Used in the Synthesis of Diazaphenoxathiin Skeleton:
Specifically, 2,4-Dihydroxypyridine plays a crucial role in the synthesis of the diazaphenoxathiin skeleton, which is a complex organic structure with potential applications in medicinal chemistry and drug development. The incorporation of 2,4-dihydroxypyridine into this skeleton contributes to the overall stability and reactivity of the final product, making it a valuable component in the synthesis process.
Check Digit Verification of cas no
The CAS Registry Mumber 626-03-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 626-03:
(5*6)+(4*2)+(3*6)+(2*0)+(1*3)=59
59 % 10 = 9
So 626-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N2O4/c8-3-1-2-6-5(9)4(3)7(10)11/h1-2H,(H2,6,8,9)
626-03-9Relevant articles and documents
Small molecule inhibitors of anthrax edema factor
Jiao, Guan-Sheng,Kim, Seongjin,Moayeri, Mahtab,Thai, April,Cregar-Hernandez, Lynne,McKasson, Linda,O'Malley, Sean,Leppla, Stephen H.,Johnson, Alan T.
supporting information, p. 134 - 139 (2017/12/06)
Anthrax is a highly lethal disease caused by the Gram-(+) bacteria Bacillus anthracis. Edema toxin (ET) is a major contributor to the pathogenesis of disease in humans exposed to B. anthracis. ET is a bipartite toxin composed of two proteins secreted by the vegetative bacteria, edema factor (EF) and protective antigen (PA). Our work towards identifying a small molecule inhibitor of anthrax edema factor is the subject of this letter. First we demonstrate that the small molecule probe 5′-Fluorosulfonylbenzoyl 5′-adenosine (FSBA) reacts irreversibly with EF and blocks enzymatic activity. We then show that the adenosine portion of FSBA can be replaced to provide more drug-like molecules which are up to 1000-fold more potent against EF relative to FSBA, display low cross reactivity when tested against a panel of kinases, and are nanomolar inhibitors of EF in a cell-based assay of cAMP production.
Demethylation of methoxypyridines with sodium trimethylsilanethiolate
Shiao, Min-Jen,Ku, Wei-Shen,Hwu, Jih Ru
, p. 323 - 328 (2007/10/02)
Demethylation of methoxypyridines was accomplished in 55-87percent yield by use of ca. 1.5-2.5 equivalents of NaSSiMe3 in 1,3-dimethyl-2-imidazolidinone at 120-180 deg C.This method was found applicable to a methoxyquinoline and methoxypyridines containing a second substituent, such as Cl, OMe, and COOMe.