62642-59-5

Basic information

• Product Name: 4-DIETHYLAMINOMETHYL-BENZOIC ACID
• Synonyms: 4-DIETHYLAMINOMETHYL-BENZOIC ACID;AKOS BB-9416;Benzoic acid, 4-[(diethylaMino)Methyl]-
• CAS NO: 62642-59-5
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 62642-59-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 145-146 °C
• Boiling Point: 315.4°C at 760 mmHg
• Flash Point: 144.6°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.000185mmHg at 25°C
• Refractive Index: 1.542
• PKA: 4.03±0.10(Predicted)
• CAS DataBase Reference: 4-DIETHYLAMINOMETHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIETHYLAMINOMETHYL-BENZOIC ACID(62642-59-5)
• EPA Substance Registry System: 4-DIETHYLAMINOMETHYL-BENZOIC ACID(62642-59-5)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 62642-59-5(Hazardous Substances Data)

Usage

General Description

4-Diethylaminomethyl-benzoic acid is a chemical compound with the molecular formula C13H19NO2. It is commonly used as a local anesthetic and also as a radiation protective agent. 4-DIETHYLAMINOMETHYL-BENZOIC ACID is a derivative of benzoic acid, with a diethylamino methyl group attached to the benzene ring. It has a wide range of applications in the medical field, particularly in the field of dentistry and oral surgery. The compound is known for its ability to provide effective pain relief and is commonly used in dental anesthesia, as well as in topical sprays and creams for the treatment of minor skin irritations and burns. Its chemical properties make it an important ingredient in pharmaceuticals and medical products.

InChI:InChI=1/C12H17NO2/c1-3-13(4-2)9-10-5-7-11(8-6-10)12(14)15/h5-8H,3-4,9H2,1-2H3,(H,14,15)

Upstream product

• 69293-74-9 p-(diethylaminomethyl)benzonitrile 
• 1642-81-5 p-(chloromethyl)benzoic acid 
• 109-89-7 diethylamine 
• 1571-08-0 methyl 4-formylbenzoate 
• 68453-55-4 methyl 4-((diethylamino)methyl)benzoate 

Downstream Products

• 78329-96-1 4-diethylaminomethyl-benzoic acid-(3-dibutylamino-propyl ester) 
• 154602-54-7 4t-diethylaminomethyl-cyclohexane-r-carboxylic acid 
• 99-94-5 p-Toluic acid 
• 109-89-7 diethylamine 
• 947304-01-0 C₃₀H₄₃N₃O₄ 
• 947304-06-5 C₂₉H₃₉Cl₂N₃O₃ 
• 947304-07-6 C₂₉H₄₀ClN₃O₃ 
• 947304-03-2 C₂₉H₄₀ClN₃O₃ 
• 947304-09-8 C₃₀H₄₃N₃O₃ 
• 947304-10-1 C₃₁H₄₅N₃O₄ 
• 1401000-00-7 C₂₀H₂₃N₃O₂S 
• 80335-46-2 4-(Diethylaminomethyl)benzoyl chloride 

Relevant articles and documents

Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents

In present study, 4-anilinoquinazolines scaffold, arylurea and tertiary amine moiety were combined to design, synthesize gefitinib analogs and discover novel anticancer agents. A series of 4-anilinoquinazoline derivatives (1, 2, 3 and 4) bearing arylurea and tertiary amine moiety at its 6-position were synthesized. Their antiproliferative activities in vitro were evaluated via MTT assay against A431 cell and A549 cell. The SAR of the title compounds was discussed. The compounds 2d, 2i and 2j with potent antiproliferative activities were evaluated their inhibitory activity against EGFR-TK. Compound 2j displayed potent inhibitory activity against EGFR-TK. In addition, compound 2j, at 50 mg/kg, can completely inhibit cancer growth in established nude mouse A549 xenograft model in vivo. These results suggest that the 4-anilinoquinazoline derivatives bearing diarylurea and tertiary amino moiety at its 6-position can serve as anticancer agents and EGFR inhibitors.

Quaternary bis-ammonium salt precursors and their uses as prodrugs having an antiparasitic activity

The invention concerns drug precursors with antimalarial effect, characterised in that it consists in quaternary bis-ammonium salts of general formula (I) wherein A and A′, identical or different, are respectively either a group A1 and A′1 of formula (1)