62662-74-2Relevant articles and documents
Nickel(II)- And Silver(I)-Catalyzed C-H Bond Halogenation of Anilides and Carbamates
Kianmehr, Ebrahim,Afaridoun, Hadi
, p. 1513 - 1523 (2020/12/14)
ortho -C-H bond halogenation of anilides and N -aryl carbamates using easily available N -halosuccinimides (NXS) as the active halogenation reagent in the presence of nickel or silver catalyst has been developed. This method provides a new approach to 2-haloanilides and carbamates, which may serve as starting materials for the synthesis of pharmaceutically and biologically active compounds.
Novel and efficient heterogeneous polymer supported copper catalyst for synthesis of 2-substituted Benzoxazoles from 2-Haloanilides
Saranya, Thachora Venu,Sruthi, Pambingal Rajan,Raj, Veena,Anas, Saithalavi
supporting information, (2021/02/27)
A novel polymer supported copper complex is prepared by the immobilization of copper iodide on chemically modified polyacrylonitrile and its application in heterogeneous catalysis is described. The catalyst was prepared by easy method via synthetic modification of Polyacrylonitrile (PAN) using ethylene diamine followed by the complexation with CuI. After characterization, this complex was explored as a green and efficient heterogeneous catalyst for the synthesis of 2-benzoxazoles from 2-haloanilides. The reaction was performed without adding additional ligand and the catalyst shows activity over a broad range of substrates with quantitative product yields. The catalyst was easily recovered by simple filtration and reused successfully for further cycle.
Synthesis method of 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate
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Paragraph 0067-0073, (2019/10/01)
The invention provides a synthesis method of a 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate. The synthesis method comprises the following steps of dissolving o-halogenated aniline in an organic solvent, then adding alkali, then adding an acylating agent, and carrying out an acylation reaction between the o-halogenated aniline and the acylating agent under an alkaline condition to obtaina compound I; carrying out a chlorination reaction between the compound I and a chlorinating agent under a weakly alkaline condition to obtain a compound II; adopting the compound II and magnesium for a reaction in an environment of inert gas to obtain a Grignard reagent intermediate, and carrying out a reaction between the Grignard reagent intermediate and a trifluoroacetic acid derivative to obtain a compound III; carrying out a reaction between the compound III and concentrated hydrochloric acid to obtain the 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate. According to the synthesis method, the reaction condition is mild, the adopted raw materials are easy to obtain, the price is low, the total yield of the prepared target product can reach 80.35%, the purity can reach 99.8%,and the synthesis method is suitable for industrial production.