628-64-8

Basic information

• Product Name: 2-Ethoxyethyl chloroformate
• Synonyms: 2-Ethoxyethyl chloroformate;Chlorocarbonic acid 2-ethoxy-ethyl ester;2-Ethoxyethyl chlorocarbonate;Carbonochloridic acid, 2-ethoxyethyl este;Chloroformic acid (2-ethoxyethyl) ester;chlorocarbonic 2-ethoxyethyl ester;2-ethoxyethyl carbonochloridate
• CAS NO: 628-64-8
• Molecular Formula: C₅H₉ClO₃
• Molecular Weight: 152.58
• EINECS: 211-048-9
• Product Categories: API intermediates
• Mol File: 628-64-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 210.66°C (rough estimate)
• Flash Point: 61.2 °C
• Appearance: /
• Density: 1.1341
• Vapor Pressure: 1.96mmHg at 25°C
• Refractive Index: 1.4169 (estimate)
• CAS DataBase Reference: 2-Ethoxyethyl chloroformate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxyethyl chloroformate(628-64-8)
• EPA Substance Registry System: 2-Ethoxyethyl chloroformate(628-64-8)

Safety Data

• Hazardous Substances Data: 628-64-8(Hazardous Substances Data)

Usage

General Description

2-Ethoxyethyl chloroformate is a type of organic compound that is classified under the category of acid halides. This volatile liquid has a strong irritating odor and is clear to yellowish in color. Apart from its industrial applications, it is used commonly as a reagent in organic synthesis, in particular, for the production of pharmaceuticals and pesticides. However, it is identified as a potentially harmful chemical, capable of causing burns and severe eye damage upon direct contact. It is also harmful if ingested or inhaled, pointing to the need for proper handling and usage at all times.

InChI:InChI=1/C5H9ClO3/c1-2-8-3-4-9-5(6)7/h2-4H2,1H3

Upstream product

• 110-80-5 2-ethoxy-ethanol 
• 75-44-5 phosgene 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 35266-28-5 C₁₂H₁₅N₃O₅S 
• 83264-11-3 (4-hydroxy-phenyl)-carbamic acid-(2-ethoxy-ethyl ester) 
• 52373-74-7 di-(2-ethoxyethyl)peroxydicarbonate 
• 83264-02-2 (4-Oxiranylmethoxy-phenyl)-carbamic acid 2-ethoxy-ethyl ester 
• 83263-69-8 [4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-carbamic acid 2-ethoxy-ethyl ester 

Relevant articles and documents

CONTROLLED RELEASE PREPARATION

A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a tablet, granule or fine granule wherein the release of active ingredient is controlled and a gel-forming polymer. Said tablet, granule or fine granule has a release-controlled coating-layer formed on a core particle containing an active ingredient.

CONTROLLED RELEASE COMPOSITION

The present invention provides a controlled release composition showing release of an active ingredient (proton pump inhibitor) controlled in two or more steps at different release rates, which contains1) a release-controlled part A capable of controlling release of the active ingredient to occur at a predetermined rate,2) a release-controlled part B capable of controlling release of the active ingredient to occur at a predetermined rate lower than the release rate of the release-controlled part A, and where necessary, 3) a release-controlled part C capable of controlling release of the active ingredient to occur at a predetermined rate faster than the release rate of the release-controlled part B, wherein the release of the active ingredient from the release-controlled part B precedes the release of the active ingredient from the release-controlled part A (when release-controlled part C is contained, the release of the active ingredient from the release-controlled part C precedes the release of the active ingredient from the release-controlled part B).

KINETICS AND MECHANISM OF PHOSGENATION OF ALIPHATIC ALCOHOLS. IV. EFFECT OF HYDROGEN CHLORIDE ON THE REACTION RATE

The reaction of phosgene with alcohols is inhibited by hydrogen chloride.Here, as shown for the model methanolysis of methyl chloroformate, the halide ions have practically no effect on the reaction rate.The inhibition is due to the formation of associates, which do not possess nucleophilic characteristics between the alcohol and the hydrogen chloride.In proton-inert solvents at low temperatures the reaction only goes to the extent of a third on account of the formation of a stable unreactive 2:1 associate of the alcohol with hydrogen chloride.