6283-98-3

Basic information

• Product Name: N-benzylhexanamide
• CAS NO: 6283-98-3
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.2961
• Mol File: 6283-98-3.mol
• Article Data: 64

Chemical Properties

• Boiling Point: 378.4°C at 760 mmHg
• Flash Point: 227.9°C
• Density: 0.974g/cm³
• Vapor Pressure: 6.31E-06mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: N-benzylhexanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzylhexanamide(6283-98-3)
• EPA Substance Registry System: N-benzylhexanamide(6283-98-3)

Safety Data

• Hazardous Substances Data: 6283-98-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 142-62-1 hexanoic acid 
• 142039-54-1 5-hexa-2,4-dienoic acid benzyl amide 
• 81235-20-3 3-(benzothiazol-2-ylthio)-1,2-benzisothiazole 1,1-dioxide 
• 149-30-4 2-Mercaptobenzothiazole 
• 956-75-2 p-nitrophenyl hexanoate 
• 72531-44-3 Hexanoic acid benzotriazol-1-yl ester 
• 81245-06-9 3-(benzoxazol-2-ylthio)-1,2-benzisothiazole 1,1-dioxide 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 
• 1466-67-7 1,3-dibenzylurea 
• 628-02-4 Caproamide 
• 111-27-3 hexan-1-ol 
• 821-41-0 5-Hexen-1-ol 
• 100-52-7 benzaldehyde 

Downstream Products

• 1438857-82-9 C₁₃H₂₅NO 
• 100-46-9 benzylamine 
• 111-27-3 hexan-1-ol 
• 942-92-7 caprophenone 
• 1669-33-6 pentyl 4-methylphenyl ketone 

Relevant articles and documents

AMINE-BORANES AS BIFUNCTIONAL REAGENTS FOR DIRECT AMIDATION OF CARBOXYLIC ACIDS

The present invention generally relates to a process for selective and direct activation and subsequent amidation of aliphatic and aromatic carboxylic acids to afford an amide R3CONR1R2. That the process is capable of delivering gaseous or low-boiling point amines provides a major advantage over existing methodologies, which involves an intermediate of triacyloxyborane-amine complex [(R3CO2)3—B—NHR1R2]. This procedure readily produces primary, secondary, and tertiary amides, and is compatible with the chirality of the acid and amine involved. The preparation of known pharmaceutical molecules and intermediates has also been demonstrated.

Dehydrogenative amide synthesis from alcohols and amines utilizing N-heterocyclic carbene-based ruthenium complexes as efficient catalysts: The influence of catalyst loadings, ancillary and added ligands

The metal-catalyzed dehydrogenative coupling of alcohols and amines to access amides has been recognized as an atom-economic and environmental-friendly process. Apart from the formation of the amide products, three other kinds of compounds (esters, imines and amines) may also be produced. Therefore, it is of vital importance to investigate product distribution in this transformation. Herein, N-heterocyclic carbene-based Ru (NHC/Ru) complexes [Ru-1]-[Ru-5] with different ancillary ligands were prepared and characterized. Based on these complexes, we selected condition A (without an added NHC precursor) and condition B (with an added NHC precursor) to comprehensively explore the selectivity and yield of the desired amides. After careful evaluation of various parameters, the Ru loadings, added NHC precursors and the electronic/steric properties of ancillary NHC ligands were found to have considerable influence on this catalytic process.

Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method. This journal is